Genmab — Marts 2018
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Og til sidst: Therefore, we
envision that the combination of ADCC triggering antibodies
and KIR-ligand mismatching is a favorable combination
to be tested in future clinical studies, both in the context of
HaploSCT, potentially in combination with NK cell infusions,
as well as single donor NK-cell infusion. - Haplo... er transplantation. -
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Tak Lego. In conclusion, our findings demonstrate that NK cells, which express high levels of CD38, are reduced by daratumumab treatment in a rapid, reversible, dose- and concentration-dependent manner. This reduction in NK-cell counts was not associated with response to daratumumab or PFS. In addition, reduction of NK cells was not associated with an increase in safety concerns or AEs, including infections.
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Tak for de supplerende informationer. Hvis jeg forstår det rigtigt, så vedrører diskussionen grundlæggende den mulige brug af denne teknik http://blog.dana-farber.org/insight/2017/01/what-is-haploidentical-stem-cell-transplantation/
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