Genmab — Januar 2018
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Th1/17 hybrid T cells offer potent and durable anti-tumor response in preclinical model
Adoptive cell therapy for cancer involves harvesting T cells from a patient and expanding and sometimes modifying them in the laboratory before reinfusion. It has been challenging to create T cells that are both potent and durable. In a new study, researchers report the potent anti-tumor properties of hybrid Th1/Th17 cells that combine the cancer-fighting properties of Th1 cells and the ability of Th17 cells to self-renew and regenerate.
ScienceDaily (www.sciencedaily.com)
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"We've known about NAD+ for almost 100 years, so, for me, the best part was when we realized that this intrinsic factor was responsible for the cells' strength," says Mehrotra. "That we could pick out one molecule, CD38, and produce this robust anti-tumor phenotype just by knocking it down was a big surprise. I actually thought that it wouldn't work-that we wouldn't get robust tumor control with the CD38 knockout cells. But it turns out that its ability to regulate the important cofactor NAD+ is
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