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Genmab — Januar 2018

Planlagt Fastgjort Låst Flyttet Genmab
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  • BulderB Offline
    BulderB Offline
    Bulder
    wrote on sidst redigeret af
    #2148

    Men senere står der: ...high capacity for killing cancer cells expressing high or low levels of HER2 when administered as an antibody drug conjugate (ADC), no substantial agonistic effect on the proliferation of HER2-expressing cancer cells, and provide for effective ADCC-mediated killing of HER2-expressing cells, as well as any combination of the foregoing properties.

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    • BulderB Offline
      BulderB Offline
      Bulder
      wrote on sidst redigeret af
      #2149

      Så det er sikkert ligesom Tiso. Kan noget ADCC på egen hånd, men virker bedst konjugeret med et giftstof.

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      • S Offline
        S Offline
        Sukkeralf
        wrote on sidst redigeret af
        #2150

        Er det tid til en fredagsnyhed

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        • BulderB Offline
          BulderB Offline
          Bulder
          wrote on sidst redigeret af
          #2151

          Alene i DK er der 4700 personer/år der udvikler brystkræft. Og hvis 20% af disse overudtrykker HER2 med dårlig prognose, så er behovet stort på verdensplan.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #2152

            Is it pure coïncidence that this company (in Utrecht, just next to Genmab) announces first dosing of bispecific antibody targeting HER2 and HER3 receptors today?? Merus Announces First Patient Dosed in a Phase 2 Clinical Trial of MCLA-128 in Two Metastatic Breast Cancer Patient Populations
            https://www.pharmiweb.com/pressreleases/pressrel.asp?ROW_ID=262078

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #2153

              Det er bare et hårdt prøvet target

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              • E Offline
                E Offline
                E_L
                wrote on sidst redigeret af
                #2154

                A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens https://clinicaltrials.gov/ct2/show/NCT03412565?term=daratumumab+OR+ofatumumab&lupd_s=01%2F25%2F2018&rank=4

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #2155

                  this could become a very important study, backbone Dara, choose what combo you want, D-VRd , D-VMP or D-Rd.

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #2156

                    completion date sept 19, very fast?

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #2157

                      Phase 2. Will they file?

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                      • A Offline
                        A Offline
                        AaBforever
                        wrote on sidst redigeret af
                        #2158

                        Det går squ´meget godt nu 🙂

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                        • A Offline
                          A Offline
                          AaBforever
                          wrote on sidst redigeret af
                          #2159

                          Som sagt før " Genmab er som en rutschebane i Fårup...det går SÅ hurtigt ned og OP 🙂

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #2160

                            good point. thinking out-loud; we already have the SubQ vs IV study which is Phase 3; maybe this is the Ph2 we need in the middle to get that one approved?

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #2161

                              we had a similar situation before, no?

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #2162

                                I mean, the IV combo's should be approved by then?

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #2163

                                  sorry, not should be , WILL be 😉

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                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #2164

                                    Do you ask Winkel if this means that these 2 studies can be the basis for an overall approval of sc in all lines and settings?

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #2165

                                      ok - good idea

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                                      • BulderB Offline
                                        BulderB Offline
                                        Bulder
                                        wrote on sidst redigeret af
                                        #2166

                                        If so, it means that sc can be launched in 2020. - Just like Novod predicts.

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                                        • Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktør
                                          wrote on sidst redigeret af
                                          #2167

                                          Vi kan vist stadig være enig om at shorterne i aktien er meget venlige og humane. Vi ser absolut ingen aggressivitet og forsøg på at trykke kursen ned under støttepunkter og udløse stop loses over en bred kam.

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