Genmab — December 2017
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God morgen, Why do I have to think of JvdW when reading this manuscript title: "CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells"
https://academic.oup.com/carcin/advance-article-abstract/doi/10.1093/carcin/bgx137/4712089?redirectedFrom=fulltext #Knockout #Knockoff -
Adam Cohen BCMA car-t + cyc https://www.youtube.com/watch?v=jsl4k3fD_Mo https://ash.confex.com/ash/2017/webprogram/Paper106279.html
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@E L...'knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.' - Wikipedia. Her har man fjernet det gen der producerer CD38 og det har JwdW nok ikke stået for;).
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@E L ...sorry for citing such a stupid source;))..her is one from 'Nature'...'gene knockout
Permanent change in DNA leading to the loss of function of a gene, caused by a manipulation of the organism's DNA in a laboratory followed by breeding to produce a population of organisms that are homozygotes for the changed gene.
Jon Moulton'
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Syros SY-1425
clinical data - https://ir.syros.com/press-releases/detail/113/syros-announces-initial-clinical-data-from-ongoing-phase-2 -
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»Nu har vi en tredjelinjebehandling, der holder tre fjerdedele af patienterne i live små tre år efter behandlingsstart. Der er altså tale om patienter, der havde meget dårlige fremtidsudsigter. Så det er ret vildt. Det er virkelig en revolution i behandlingen af myolomatose,« siger Torben Plesner.
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