Genmab — December 2017
-
-
Ja CDC-effekten forstærkes (og desuden også immuneffekten) af hexabody-klyngen. Men hvordan foregår kombinationen med et bispecifikt antistof? http://www.genmab.com/hexabody/Technology
-
Medwatch Morphosys alm info: http://medwatch.dk/secure/Medicinal___Biotek/article10073937.ece
-
-
Mit første gæt på duohexabodien kl 10.15 var vist temmelig forkert. Der må være tale om at de 6 antistoffer, som via hexabody teknologien har fået forbedret evnen til at danne klynger af 6 - simpelthen er bispecifikke. https://www.nature.com/scibx/journal/v7/n13/full/scibx.2014.363.html#f1
-
Nu er markedet negativt i dag pga Trumps skattesænkninger er udskudt. Så er det ikke så underligt at Genmab falder
https://www.cnbc.com/2017/11/30/senate-pushes-back-tax-bill-vote-as-setback-hits-in-final-hours.html -
....Building on our in-depth understanding of the mechanism of IgG4 Fab-arm exchange, we developed a powerful platform for the generation of stable bispecific IgG1 antibodies: the DuoBody platform. http://www.genmab.com/duobody/biology
-
-
@Doc4: Dit sidste link virker ikke. Jeg havde forstået det sådan at hexabody er 6 enkelte antistofmolekyler der danner en ring/sekskant med Fc-regionen mod centrum. Og at i en duohexabody er hver af disse antistofmolekyler bispecifikke. Er det ikke rigtigt?
-
-
..full article (PLOS er altid gratis)..http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002344
-
...Each heavy-light chain pair represents an IgG Fab-arm (or half-molecule)...once they are secreted by the B cell into the blood, they engage in a unique process, called Fab-arm exchange, in which they become bispecific http://www.genmab.com/duobody/biology...duobody går på, at man springer et led over - det er fremstillet i den aktive form, hvor kroppen først sammensætter 2x monospecifikke til bispecifikke (duobodies) når de entrer blodbanen (1x tung + 1x let kæde)
-
sig mig - pt. findes der vel ikke nogen markedsgodkendte bi-specifikke antistoffer?
-
...prøver lige igen med links..det ser ud til Proinvestors link manager 'digter' lidt....hexabody PLOS http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002344...hexabody Genmab http://www.genmab.com/hexabody/news/hexabody-platform-published-in-plos-biology
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Tilmeld Log ind