Genmab — November 2017
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Mulig Darzalex-rival får genvej i både USA og Europa
En CAR-T-celleterapi mod knoglemarvskræft fra amerikanske Bluebird Bio har fået særstatus fra myndighederne i både USA og EU, hvor det med tiden kan blive udfordrer til Genmabs Darzalex. Bluebird-midlet er rettet mod et biologisk mål, som det danske biotekselskab også arbejder med.
(medwatch.dk)
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Det er i hvert fald en teknologi, der skal holdes gevaldigt øje med
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bb2121 er muligvis ikke så farlig, men der arbejdes overalt med at forbedre CAR-T´s dårlige egenskaber og der kastes voldsomt mange penge efter det. Eksempelv off the shelves CAR-T eller CAR-T givet flere gange i mindre doser eller CAr-T monteret med en switch, så man kan lukke ned for T-cellerne, hvis bivirkningerne bliver for store
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Hold da op, det lyder som artificial intelligens
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Two therapeutic areas came under the spotlight: CAR-T and Alzheimer.
Gilead’s Yescarta became the second CAR-T therapy to be approved in
the US. Interesting to remember that Gilead pocketed Kite pharma
merely six weeks before Kite’s developed drug got approved for
aggressive B-cell non-Hodgkin lymphoma. Despite being approved in two
different indications for now, commercial expansion could soon put
Yescarta and Novartis’s Kymriah in direct competition. With Yescarta
priced at $373k (i.e., $102k -
Og hvis eksempelvis daratumumabs peaksale på 8 milliarder består af en omsætning på 1-2 milliard i 3-4 linie, så vil der stadig være en del af dette som er i fare enten fra CAR-T BCMA, BCMA/CD3 eller BCMA ADC - dette target vil få kandidater igennem er jeg overbevist om og hvilken rolle det vil spille må tiden vise, men blankt at afvise det får betydning for Darzalex peak er lige arrogant nok.
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Fully agree. Jan does not seem to realise that CAR-T has serious attention from an investor point of view. I would really like him to address this more. If he is that confident that it isnt a threat, he should be more vocal in reassuring investors of this fact
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JDW say nothing because he has nothing to say! What should he possible say? If he say its absolute no threat he will lye, if he says it a good drug and will take some of there sale, he would be follish especially if he think the company is "under attack" and in danger og being bougth or ?
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