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Genmab — Oktober 2017

Planlagt Fastgjort Låst Flyttet Genmab
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  • S Offline
    S Offline
    Sukkeralf
    wrote on sidst redigeret af
    #2230

    Novartis management suggested that siponimod could act as a "bridge" between its marketed oral MS therapy Gilenya and ofatumumab, an anti-CD20 monoclonal antibody that is in two Phase III studies for relapsing MS.

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    • S Offline
      S Offline
      Sukkeralf
      wrote on sidst redigeret af
      #2231

      Ofatumumab – marketed already as the chronic lymphocytic leukaemia treatment Arzerra – could emerge as a key competitor to Ocrevus, which is enjoying a strong launch in the US market. Furthermore, Novartis believes its product could benefit from a number of advantages; ofatumumab is a fully-human monoclonal antibody (Ocrevus is humanised), it can be administered via subcutaneous injection (instead of intravenously) and

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      • S Offline
        S Offline
        Sukkeralf
        wrote on sidst redigeret af
        #2232

        based on cross-trial comparisons, it has demonstrated faster B-cell repletion. These factors could determine that ofatumumab is a more patient and physician-friendly treatment, argues Novartis; a view shared by KOLs recently interviewed by FirstWord for our forthcoming report. Phase III studies should complete in 2019.

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        • DarvinD Offline
          DarvinD Offline
          Darvin
          wrote on sidst redigeret af
          #2233

          Dejlige linier og link Sukker - tak for det

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          • Helge_LarsenPI-redaktørH Offline
            Helge_LarsenPI-redaktørH Offline
            Helge_LarsenPI-redaktør
            wrote on sidst redigeret af
            #2234

            God morgen:-)

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            • SolsenS Offline
              SolsenS Offline
              Solsen
              wrote on sidst redigeret af
              #2235

              Har du et link

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              • N Offline
                N Offline
                NextLifeDK
                wrote on sidst redigeret af
                #2236

                6:43

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                • StockBullS Offline
                  StockBullS Offline
                  StockBull
                  wrote on sidst redigeret af
                  #2237

                  @Sukkeralf: Hvor stort mon the potentielle marked er for Ofatumumab og hvornår begynder der mon at komme pæne betalinger til Genmab

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                  • G Offline
                    G Offline
                    gentogen
                    wrote on sidst redigeret af
                    #2238

                    A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-54767414 (Daratumumab) in Healthy Participants

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                    • G Offline
                      G Offline
                      gentogen
                      wrote on sidst redigeret af
                      #2239

                      ClinicalTrials.gov

                      favicon

                      (clinicaltrials.gov)

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                      • S Offline
                        S Offline
                        Sukkeralf
                        wrote on sidst redigeret af
                        #2240

                        Stock bull er spået til at blive multi BB - tror det var 3-4 millarder dollars i omsætning. Så lad os håbe at Novartis kan få et BB stof ud af ofatumumab, hvis data er gode. En godkendelse kan være i hus i 2020 og royalty for de autoimmune sygdomme ligger vist på 15% eller husker jeg forkert ?

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                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #2241

                          StockBull Ocrevus er spået til at blive en multi BB............

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                          • J Offline
                            J Offline
                            jkj
                            wrote on sidst redigeret af
                            #2242

                            Fatter ikke hvad det forsøg går ud på gentogen, kan du eller anden forklare ?

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #2243

                              Næh man synes det burde været lavet for lang tid siden

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                              • S Offline
                                S Offline
                                Sukkeralf
                                wrote on sidst redigeret af
                                #2244

                                Og hvis det var noget man virkelig gerne ville vide, så kunne det vel udføres ekstremt hurtigt, så det virker måske mere som nogle data der blot skal være klar ved indsendelse af registeringsansøgning

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #2245

                                  it looks like a safety study to test the safety of subcutaneous dosing on healthy participants ?

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                                  • E Offline
                                    E Offline
                                    E_L
                                    wrote on sidst redigeret af
                                    #2246

                                    On Teprotumumab I add the link to the genmab site
                                    (i doubt many will know it has anything to do with Genmab...) http://www.genmab.com/product-pipeline/products-in-development/teprotumumab#tab1

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                                    • BulderB Offline
                                      BulderB Offline
                                      Bulder
                                      wrote on sidst redigeret af
                                      #2247

                                      jkj: der er for at undersøge hvad dara gør ved kroppen og hvordan kroppen reagerer på dara sammenlignet med raske mennesker, som ikke får dara. Og så er det for at undersøge om præmedicinering med steroider gør nogen forskel.

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #2248

                                        I can not remember seeing a dara test on healthy people before, is it a first? -
                                        maybe we can all enroll?? 😉

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                                        • BulderB Offline
                                          BulderB Offline
                                          Bulder
                                          wrote on sidst redigeret af
                                          #2249

                                          I think it is the first - only if they pay well

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