Genmab — September 2017
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God morgen.
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https://labiotech.eu/jan-van-de-winkel-genmab-interview/ Interview med Winkel
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Her er lidt flash "On Friday afternoon at ESMO in Madrid, Dr Vergote et al presented updated ph I/II data for Genmab/Seattle Genetics’ tissue factor ADC Tisotumab Vedotin (TV) in advanced cervical cancer. Following the presentation of the data, Dr Mansoor Mirza also provided an independent review/discussion of the data as well as his view on the next steps for this drug, the potential regulatory route as well as the potential for this drug if eventually approved. Overall, the updated data for TV
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showing an overall response rate (ORR) of 32% with a long duration of response in these heavily pre-treated and extremely sick patients, were very encouraging and the independent data reviewer highlighted that this drug could have a future position as the standard of care in cervical cancer. In that respect, it must be noted that despite Avastin getting approved in 2014 on top of chemo for cervical cancer, the improvement in survival for these patients has been extremely modest over the past sev
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several decades – hence the unmet medical need is huge. We do not yet include TV in our Genmab valuation, but it could offer significant potential if it is positioned as the new standard of care for cervical cancer (likely up to USD ~1bn in peak sales). We remain buyers of Genmab."
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32% ORR in advanced Cervical Cancer looks very promisingDr Vergote et all presented very encouraging data for Genmab/Seattle Genetics’ tissue factor conjugated antibody (ADC) in advanced Cervical Cancer on Friday at ESMO. As can be seen from the waterfall plot in Figure 1 below, the overall response rate (ORR) was 32% and as illustrated in Figure 2, this is strongly above what is normally seen for this type of advanced cervical cancer patients. What is also highly encouraging from the TV ph I/II
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