Genmab — Juli 2017
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Det er lige det. Seler og livrem analyser i biotek er i bedste fald ubrugelige
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Man vel forestille sig at for de patienter der ikke får dara I 1. linie, vil få det I anden linie, når første behandling ikke mere virker
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SC dara maintenance, darkombo med andre medikamenter og så kan dara nok alligevel ikke forvente 100pct penetration i 1st line
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Så dara vil nok ændre landskabet markant
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Ja. This trial will assess the safety and efficacy of an induction therapy using the combination of dexamethasone, lenalidomide (revlimid), daratumumab (Darzalex) and carfilzomib (Kyprolis) to treat patients with newly diagnosed multiple myeloma. The therapy with KRdD (Kyprolis, Revlimid, dexamethasone, Darzalex) will be followed by autologous hematopoietic cell transplantation (auto-HCT) and KRdD consolidation.
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Indtil nu har vi ikke hørt, at der er nogen der er kureret af dara og taget af behandling - så maintenance i 5-10 for mange der behandles first line vil skæppe godt i kassen. Antallet af second- og senere linier vil mindskes i de kommende år, hvis first line kommer ud med mega succes.
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US integrated Darzalex sales figures for June have been released by Symphony Health Solutions. Darzalex sales were USD 81.5m in June versus USD 80.3m in May. These numbers are similar to the institutional sales numbers released by Symphony last week.
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Fra Nordea: We expect Darzalex sales to accelerate in H2 2017, fuelled by increased penetration in second-line MM, the label expansion with Pomalyst in the US, and additional launches in Europe with a much broader second-line label. The traction in the second-line setting is likely to be the main driver for a further acceleration in sales.
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