Genmab — Juni 2017

[KWC]

Copenhagen, Denmark; June 16, 2017 — Genmab A/S (Nasdaq Copenhagen: GEN) announced today preliminary data from the ongoing Phase I/II study of tisotumab vedotin in solid tumors (GEN701). In Part 2 of the study, 11 of 34 evaluable patients in the cervical cancer cohort achieved a response; with a median time of treatment of 4.9 months, 7 responders are still ongoing or in follow up for progression. The safety profile of tisotumab vedotin was consistent with known MMAE based antibody-drug conjuga

[JKY_VH]

tak KWC

[KWC]

conjugates (ADC), including peripheral neuropathy and neutropenia. Additionally, conjunctivitis was identified as a tisotumab vedotin specific toxicity, which led to introducing of prophylactic management. In the cervical cancer cohort, 15 patients experienced one or more Grade 3 adverse events: gastro-intestinal related (5 patients), anemia (2 patients), infections (1 patient), neuropathy (2 patients), bleeding (2 patients), other (10 patients).

[KWC]

Genmab is considering plans for further clinical development of tisotumab vedotin in cervical cancer. The GEN701 study is ongoing and further data in both cervical cancer and other solid tumor indications will be published at a later date.

[KWC]

Genmab intends to submit data from this study for presentation at an upcoming medical conference.

[flottenschmecker]

waaaad!? - nye kliniske data fra GEN!

[flottenschmecker]

mon det er trigger til at SGEN skal bestemme sig?

[KWC]

Preliminary data shows responses achieved in 11 of 34 evaluable patients with cervical cancer treated with tisotumab vedotin
Next steps in clinical development of tisotumab vedotin in this indication under active consideration

[Bulder]

Genmab Announces Preliminary Cervical Cancer Data from Tisotumab Vedotin Phase I/II Study

Company Announcement Preliminary data shows responses achieved in 11 of 34 evaluable patients with cervical cancer treated with tisotumab...

GlobeNewswire News Room (globenewswire.com)

[flottenschmecker]

ingen usædvanlig tox i studiet

[Bella1]

Snellen er stukket!

[E_L]

i am assuming off the 173 patients, 34 were cervical cancer patients and these results only apply to those?

[E_L]

the timing of this message by the way makes me think we will not get the awaited FDA approval today...

[henrik48]

Vi kan vel stadig nå FDA godkendelse efter børslukketid ?..:-)

[Budweis]

Ja, det er jo fredag

[Solsen]

That was my thought too EL

[E_L]

I am not 100% sure this is the correct place to watch on FDA site, but this was just updated to inclued 16 June and Dara is not there https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=report.page

[henrik48]

Der er da fint gang i lukkeauktionen for biotek (inkl bava)...:-)

[pauly]

slutauktionen ser ikke for god ud

[pauly]

1370 nu