Genmab — Maj 2017
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Since CD38 is one of the most strongly induced RARα target genes in response to SY-1425, AML blasts can be sensitized to DARA in a biomarker dependent manner. The preclinical synergistic effects and anticipated non-overlapping clinical toxicity profiles of the respective agents provide a strong rationale for clinical evaluation
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On average, 78% of panobinostat-treated primary myeloma cells were eliminated by daratumumab within the 4-hour ADCC assay, whereas only 51% myeloma cells were eliminated without panobinostat treatment (p<0.01). The synergistic anti-myeloma efficacy of panobinostat and daratumumab was confirmed with a panel of myeloma cell lines
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Our data demonstrate that the HDACi panobinostat induces upregulation of CD38 on myeloma and a subsequent dramatic increase of daratumumab-mediated ADCC. These data suggest that panobinostat could be used synergistically with daratumumab in a clinical setting to increase response rates and extend duration of responses to daratumumab
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Tusinde tak for info Gentogen.
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Det ser ikke ud til at smoldering-data er med på EHA? Til gengæld er der "opmuntrende" prækliniske data for dara mono i MCL og FL ! http://learningcenter.ehaweb.org/eha/2017/22nd/181145/alba.matas-cspedes.daratumumab.a.novel.human.cd38.monoclonal.antibodyfor.the.html?f=m3e1181
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God morgen.
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God morgen. Det har godt nok været nogen små kedelig dage at have Genmab i. Forhåbentligt vender det snart igen.
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