Genmab — November 2016
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KWC...Et godt budskab kan godt postes to gange.
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Enig nohope.
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"Der findes i dag allerede lægemidler, som er under udvikling i forhold til at hæmme super-enhancers og slukke for
kræftgenerne". -
Gad vide hvad det er for nogen.
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Overlæge Kirsten Grønbæk som citeres i artiklen arbejder bla. med daratumumab. http://www.bloodjournal.org/content/128/14/1814.abstract?sso-checked=true
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http://www.nature.com/ng/journal/v47/n1/abs/ng.3167.html Super enhangers med flere artikler linked
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Tak Solsen. Det er en god oversigt.
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Dykker lidt i materien, når jeg er færdig med dagens arbejde.
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Super enhancer i MM http://www.sciencedirect.com/science/article/pii/S0092867413003930
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BCMA var target i Janssens duobody og ikke BRD4 https://ash.confex.com/ash/2016/webprogram/Paper93445.html
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"
Most chromatin regulators, however, are expressed in a broad range of healthy cells and contribute generally to gene expression, so inhibition of these important genome-associated proteins might be expected to adversely affect global gene expression in healthy cells and thus produce highly toxic effects. Nonetheless, inhibitors of some chromatin regulators, such as BRD4, have been shown to selectively inhibit transcription of key oncogenic drivers such as c-MYC (hereafter referred to as MYC).. -
It is important to understand how inhibition of a widely expressed, general regulator such as BRD4 can exert a selective effect on the expression of a small number of genes in specific cells".
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