Genmab — December 2014

[Solsen]

Denne bliver slået stort op ... Patients who received carfilzomib had a progression-free survival of 26.3 months, as compared with 17.6 months (P = .0001) for those who were treated with lenalidomide and dexamethasone

[Solsen]

http://www.medscape.com/viewarticle/836077?src=wnl_edit_cfna&uac=223854SK Link til Medscape

[Solsen]

Although median overall survival was not reached in either group in this interim analysis, there was a trend toward longer overall survival in the group who received carfilzomib (73.3% vs 65%; HR = 0.79; P=.018). However, the results did not cross the prespecified statistical boundary set by the statisticians when the trial s

[Solsen]

However, the results did not cross the prespecified statistical boundary set by the statisticians when the trial started (P = .005).

[Solsen]

The overall response rates for the two groups was 87.4% in the carfilzomib group, compared with 66.9% in the control arm, and a complete response or better was achieved by 31.8% vs 9.4%.

[Solsen]

På orr og specielt cr er dara bedre. Men hvorvidt forbedringen i pfs kan påvises må tiden vise. Men pæne tal for konkurrenten her.

[Solsen]

http://finance.yahoo.com/news/amgen-onyx-announce-detailed-results-160000281.html Et link alle kan komme på. Se specielt safety 7-8% døde under eller lige efter behandling.

[gentogen]

Serious adverse reactions were reported in 45 percent of patients.

[Solsen]

En helt aktuel info direkte fra ASH siger, at Dara er voldsomt eksponeret på Janssens stand .... Dejligt !

[gentogen]

Forskellen i maintenance pfs er lidt større end tidligere udmeldt

[gentogen]

Og ja. Lyder godt

[Budweis]

ecancer

ecancer

(ecancer.org)

[Budweis]

Prof Mateos speaks to ecancertv at ASH 2014 about the results of a phase I study on the use of daratumumab, an anti-CD38 antibody, in combination with standard approaches to treat relapsed multiple myeloma.

[investor1989]

Siger hun til sidst at 100% af patienterne med Pomalyst respondere på behandling. Altså100% ORR ?

[investor1989]

Nej det hun siger er vidst at frontline patienterne i studiet responderer 100% og 50% af patienterne med pomalyst (R/R patienter)

[investor1989]

Her er en lille Amgen video http://investors.amgen.com/phoenix.zhtml?c=61656&p=irol-newsArticle&ID=1995470

[investor1989]

In the KRd and Rd groups, 14 percent versus 4.3 percent of patients achieved a stringent complete response, a measurement indicating superior depth of response... dette syntes jeg da ikke er fantastisk. Dog svært vide hvad de karakteriserer som stringent CR

[Budweis]

share-at-congress.com/?p=748

[Budweis]

In a phase Ib study among patients with newly diagnosed, relapsed or refractory multiple myeloma (MM) the combination of daratumumab with standard treatments was well tolerated and resulted in high rates of response. Results on efficacy and safety of the ongoing trial were presented at the ASH Annual Meeting in San Francisco.

[gentogen]

“This is a very new and exciting concept in multiple myeloma, as we are seeing that combining this precision approach with the standard of care is leading to more effective treatment without increased toxicity,” said lead study author Philippe Moreau, MD, of University Hospital of Nantes in France.