Genmab — September 2014
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Nej når jeg googler AXL kommer der en del om Tyrosine Kinase frem også:. Ret spændende da det jo er Imbruvicas område
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Det er altså ret spændende. Imbruvica er en Brutons Tyrosine Kinase (BTK) ... At genmab nu laver et Humax der laver Tyrosine Kinase og linker dette med et ADC lyder hot i mine øre (men jeg er ikke læge)
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AATK; ABL; ABL2; ALK; AXL; BLK; BMX; BTK; CSF1R; CSK; DDR1; DDR2; EGFR; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHA10; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; ERBB2; ERBB3; ERBB4; FER; FES; FGFR1; FGFR2; FGFR3; FGFR4; FGR; FLT1; FLT3; FLT4; FRK; FYN; GSG2; HCK; IGF1R; ILK; INSR; INSRR; IRAK4; ITK; JAK1; JAK2; JAK3; KDR; KIT; KSR1; LCK; LMTK2; LMTK3; LTK; LYN; MATK; MERTK; MET; MLTK; MST1R; MUSK; NPR1; NTRK1; NTRK2; NTRK3; PDGFRA; PDGFRB; PLK4; PTK2; PTK2B; PTK6; PTK7; RET; ROR1; ROR2
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Overexpression of Axl has been associated with invasiveness and metastasis in a wide array of human cancers including lung (Shieh et al, 2005), prostate (Sainaghiet al, 2005), breast (Meric et al., 2002; Zhang et al.,2008), gastric (Wu et al., 2002) and pancreatic (Koorstraet al, 2009) cancers, renal cell carcinoma (Chung et al.,2003) as well as glioblastoma (Vajkoczy P, et al, 2006; Hutterer et al., 2008).
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Men er det ikke den første Tyrosine Kinase som genmab laver? så helt nyt område for dem. og at de så endda vil linke ADC sammen med. Elsker at genmab er alle de hotte steder.
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Bliver spændende at høre hvad analytikerne siger om dette
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Dette samarbejde med Genmab udvider yderligere potentialet for vores brancheførende ADC-teknologi til brug sammen med nye onkologi-targets, samtidig med at vi øger den økonomiske værdiskabelse, efterhånden som programmet skrider frem," udtaler Natasha Hernday, der er direktør i Seattle Genetics i en pressemeddelelse.
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