Genmab — Oktober 2013
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Scrapværdien er enorm! Det kan ikke gå galt. Novo here we come.
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Mon ikke snarere, at vi skal sigte på Genentech, hvis vi skal have en ledestjerne
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Lidt ud i fremtiden, men Gen med: http://www.proteins-congress.com/who-is-speaking/
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Complement Activations through IgG Hexamers
Complement activation by antibodies represents a potent form of immune defense. By using cryo-electron tomography and mutagenesis studies we reveal the molecular mechanism by which antibody complexed to antigen triggers complement activation. Our data provide a model for understanding complement activation by antibodies and provides leads for its modulation.
Janine Schuurman, Ph.D., Director, Strategic Research, Genmab B.V., The Netherlands -
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Our data demonstrate that the bispecific antibody EM1-mAb, generated using
Fab arm exchange, inhibited EGFR and cMet pathways simultaneously, resulting
in superior activity in cellular downstream signaling compared to the
combination of single pathway inhibitors. -
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Sheri Moores1, Mark Chiu1, Barbara Bushey1, Kristen Chevalier1, Diana Chin1,
Susan Chippari1, Peter Haytko1, Frank McCabe1, Joost Neijssen2, Paul Parren2,
Janine Schuurman2, Sam Wu1, Ricardo Attar1, Mark Anderson1. 1Janssen R&D,
Spring House, PA; 2Genmab, Utrecht, Netherlands -
Godt fundet gentogen. Det bliver en fornøjelse at følge duobody de næste år.
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