Genmab — Februar 2013
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Hvis man sammenholder det med hvad Paul Richardson sagde på post ASH seminaret - nemlig at mulighed for hurtig godkendelse var "very real" såfremt data var gode - og det viste man i løbet af et halvt års tid, så passer det med "primary completion date"
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Hvis ikke de søger, så gør jeg
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hahaha mads. Genialt
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der er godt smæk på idag 172k nu @gen.co
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der bliver handlet igennem nu
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316K
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det er merill lynch, credit suisse på den ene side og ens og ddb på den anden side. Jeg tror det må være ATP der losser ud
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Vedr. Solsens link. Så kan Ofa måske profitere af Ibrutinib. In combination with ofatumumab (Arzerra) on patients with chronic lymphocytic leukemia / small lymphocytic leukemia / prolymphocytic leukemia1 (CLL/SLL/ PLL1) and Richter transformation, results demonstrate that the combination was well-tolerated and highly active in patients with heavily pretreated relapsed/refractory CLL/SLL. The drug is described to have a rapid onset of response, low relapse rate, and favorable safety profile.http
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In this ongoing trial patients with relapsed/refractory CLL/SLL who have received two or more prior therapies are treated with ibrutinib (420 mg) daily until disease progression, followed by concomitant ofatumumab with continued ibrutinib until progression.
For the CLL/SLL/PLL patients the overall response rate, as measured by IWCLL criteria and progression-free survival is 100%, with a median follow-up of 9.8 months
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Så de laver head to head med ofa i den indikation den er godkendt i. Det er svært at se fordelen i for Genmab.
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Ibrutinib bliver en stor spiller og også her har Janssen været vågne og villige til at betale for en god aftale. Lad os håbe at Daratumumab bliver en lige så stor succes - og ikke helt uvæsentligt, at Janssen sidder på både Ibrutinib og Daratumumab. Hvem ved det kan blive fremtidens killer-kombi uden kemo !
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Det er altså meget spændende at de gør dette med ibrutinib
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