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  4. Genmab — Februar 2024

Genmab — Februar 2024

Planlagt Fastgjort Låst Flyttet Genmab
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  • JørgenVarnæsJ Offline
    JørgenVarnæsJ Offline
    JørgenVarnæs
    wrote on sidst redigeret af
    #113

    var det ikke Novod, der kaldte set-uppet for "døde penge"

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #114

      the 50/50 split Genmab wants is a significant hurdle for partnerships with big pharma i believe. and very possibly one of the reasons some of the larger bi-specific deals we have seen over the last few months were not with genmab technology. But i can't blame them for pursuing 50/50, after what happened with JNJ, i would also not want to be in a position like that again...

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      • JørgenVarnæsJ Offline
        JørgenVarnæsJ Offline
        JørgenVarnæs
        wrote on sidst redigeret af
        #115

        But it's really not that hard - once you have run the safety/dose escalation part of the clinical development, you are in a very different place negotiation-wise. GEN has done very little of this. In fact, it seems they need to partner with other companies to have the necessary tech to even get programs into the clinic

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #116

          If Genmab want and ADC for instance they need to partner up with a ADC company like everyone else

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          • JørgenVarnæsJ Offline
            JørgenVarnæsJ Offline
            JørgenVarnæs
            wrote on sidst redigeret af
            #117

            Apart from hexa - when was the last time we saw results from the clinic on new programs?

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            • S Offline
              S Offline
              Sukkeralf
              wrote on sidst redigeret af
              #118

              Thats a good thing I think - different targets needs different tech

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              • JørgenVarnæsJ Offline
                JørgenVarnæsJ Offline
                JørgenVarnæs
                wrote on sidst redigeret af
                #119

                how is KYSO the same as the need to enter 50/50 partnerships to get something off the ground?

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                • E Offline
                  E Offline
                  E_L
                  wrote on sidst redigeret af
                  #120

                  on ADC; to be honest, i had expected something from their collaboration with Abbvie there, Jan was very enthusiastic at the time on Abbvie's ADC technology

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                  • E Offline
                    E Offline
                    E_L
                    wrote on sidst redigeret af
                    #121

                    but we haven't seen anything with Abbvie really besides epco

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #122

                      JV, epco was 50/50 after initial development

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                      • E Offline
                        E Offline
                        E_L
                        wrote on sidst redigeret af
                        #123

                        they stopped a few programs, eg HexaBody-DR5/DR5
                        , DuoHexabody-CD37, DuoBody-CD3x5T4

                        ,

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #124

                          that is not something you hope for in advance offcourse, ideally these would have gone further allready

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                          • JørgenVarnæsJ Offline
                            JørgenVarnæsJ Offline
                            JørgenVarnæs
                            wrote on sidst redigeret af
                            #125

                            EL, indeed. But where are all the other programs showing clinical promise?

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                            • JørgenVarnæsJ Offline
                              JørgenVarnæsJ Offline
                              JørgenVarnæs
                              wrote on sidst redigeret af
                              #126

                              So far we've seen nothing from the Biontech collab but vailed hints about synergistic effect. I can't point to a single thing in the pipeline with the potential to break through

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                              • R Offline
                                R Offline
                                Raun
                                wrote on sidst redigeret af
                                #127

                                Tak for din vurdering @Solsen 🙂

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                                • E Offline
                                  E Offline
                                  E_L
                                  wrote on sidst redigeret af
                                  #128

                                  well we are waiting for GEN1042 /46 data, these are overdue, like HexaCD38 seem all a bit delayed. Not sure if that is due to covid

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                                  • JørgenVarnæsJ Offline
                                    JørgenVarnæsJ Offline
                                    JørgenVarnæs
                                    wrote on sidst redigeret af
                                    #129

                                    but perhaps worse - there is a profound lack of phase 3 programs in the pipeline

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #130

                                      i their defence, the epco approval was record speed

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                                      • E Offline
                                        E Offline
                                        E_L
                                        wrote on sidst redigeret af
                                        #131

                                        you need ph1 and 2 first JV, you can't skip a stage unfortunately...

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                                        • E Offline
                                          E Offline
                                          E_L
                                          wrote on sidst redigeret af
                                          #132

                                          and to start a Ph3 you really need to think you have a winner, i know everyone thinks they have too much money, but they are very costly...

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