Aktiesnakken — Februar 2010
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5 hhv 14 trak sig fra hutexil armene
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15 fra placebo
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There was a suspsicion of a drug related death....but it turned to be related to placebo
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statistik for de 3 arme gennemgås... mht demografi. ser ret ens ud.
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Primary endpoint: significant improvement of voluntary movements.
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den lave dosisgruppe er ikke signifikant forskellig fra placebo
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den høje dosis er derimod
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det samme billede mht. doser når det kommer til "Motor function" (includes voluntary and involuntary movement)
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div vurdering af symptomer gennemgås.
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der var noget frygt mht. "chorea" (hvad det så er) men den viste sig ubegrundet
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Safety profile:
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Any adverse Events er lav ift.... ( i 60'erne %)
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disse inkluderer alt.
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over hele 6mdr perioden
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afhængig af hvad man måler svarer forbedringen i "motor functions" til ca. 6-15 mdr (sygdomsforløb)
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conclusion. Signifacantly improve motor functions
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no "thearapeutic disadvantages"... (no worsening of disease ... and no increased adverse events)
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Så er der Q&A.
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Novod, handelsbanken:
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any cross read to be made with HART-study i USA.... særligt 3 vs 6mdr?
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