Anavex Ny tråd juli 2024
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Anavex
@Tasso1
Skal vi ikke starte med at få deres forskning gransket af uvildige?
Ingen løfter er indfriet endnu. Intet er indsendt - heller ikke et peer review.
Jeg synes vi er meget, meget langt fra en godkendelse. Anavex har mig bekendt heller ikke overholdt en deadline endnu. Har de overhovedet en deadline? Nuvel, sagde Missling noget med inden årsskiftet? Jeg vil se det før jeg tror det! Der har været for mange skuffelser i forløbet. -
Jeg vurderer at Marwan Sabbagh primært har sit eget brand at bekymre sig om. At Sabbagh vælger at stå inde for Anavex' AD case anser jeg som en meget væsentlig indikator på at der bedrives videnskab.
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Helt enig D4500, professor Sabbagh's mening tæller som uvildig for mig også, selvom han er konsulent for Anavex.
Den gode doktor sagde:
"These data are very exciting, particularly in a study that can demonstrate objective slowing of markers of neurodegeneration," lead investigator Marwan Sabbagh, MD, a behavioral neurologist at Barrow Neurological Institute, said in a statement.1 "The advantage of blarcamesine is that it is a small oral molecule that exerts clinical benefits on cognition and neurodegeneration and could be appealing because of its route of administration and good comparative safety profile. The neuroimaging evaluation performed in the Phase IIb/III study demonstrated no neurological tissue damage such as hemorrhage or Amyloid-related imaging abnormalities (ARIA), as documented with other anti-amyloid targeted therapies."
Den gode doktors ry og rygte er utvivlsomt vigtigt for ham og nok mest vigtigt, at hjælpe disse mennesker.
Nuværende MC er meget meget lavt efter min mening.
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@kyed01
I min bog kan man ikke være betalt af en virksomhed og samtidig være uvildig ift den pågældende virksomhed. Det kan man heller ikke officielt. Derfor man skal udfylde en disclosure statement ifm. publikation eller præsentation.
Man kan have et godt ry indtil man får et dårligt. Og mig bekendt kan penge købe mangt og meget. -
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=39097
Har ikke fundet ud af om det er blevet til noget. -
Måske er det bedst at sætte pengene på novo??
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Anavex NOVO fase 2 GLP-data AAIC
GLP vejen er heller ikke helt tosset.
Kognitive data er tilsyneladende med de kun 18 % bedre end placebo, dog kun ca. halv så godt som ved Blarcamsine.
GLP`s evne til at reducerer tabet af hjernevæv matcher nogenlunde Blarcamsine, dog uden at kunne se detaljerne.
Så ja - NOVO er dygtige og skal nok blive en vigtig spiller på Alzheimer området, men som tidligere nævnt, så vil der sandsynligvis i fremtiden blive brug for en bred vifte af angrebsvinkler på Alzheimer (og andre CNS indikationer) ift. den enkelt patient og stadet i indikationen mm.
Derfor kunne et evt. samarbejde mellem Anavex og NOVO være en rigtig god løsning.
NOVO er dog så store, at de sandsynligvis nok bare ville købe Anavex.
De ville få et helt nyt tilskud til deres pipeline med Sigma-1 tilgangen og samtidig have en potentiel konkurrent mindre af slås med.New research suggests that Novo Nordisk's GLP-1 agonist liraglutide can protect the brains of people with mild Alzheimer's disease, slowing cognitive decline by as much as 18% after one year of treatment versus placebo. The Phase IIb study findings were reported Tuesday at the Alzheimer's Association International Conference (AAIC).
However, the secondary goal of change in scores for clinical and cognitive measures, as well as the exploratory endpoint of brain volume, showed statistically significant benefit. Results demonstrated that people in the study who received liraglutide had nearly 50% less volume loss in several areas of the brain, including frontal, temporal, parietal and total grey matter, as measured by MRI.
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Jeg har undersøgt Dr Marwan Sabbagh lidt mere og jeg er noget skuffet.
Han er en betalt lejesvend til alle der betaler ser det ud til, også de firmaer som sælger mediciner der giver hjerneblødning.
Jeg må desværre give dig ret Boersboe, ser ud til at han vil arbejde for stort set alle der betaler ved kasse 1, inklusive vores egen Novo Nordisk.
Han har yderligere været i bestyrelsen af Cortexyme (Nasdaq: CRTX) som ikke eksisterer mere, skriftede navn til Quince som er i ryg marv sygdomme.Dr. Sabbagh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Dr. Sabbagh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genetech=Roche. Dr. Sabbagh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novo Nordisk. Dr. Sabbagh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lilly. Dr. Sabbagh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Synaptogenix. Dr. Sabbagh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Signant Health. Dr. Sabbagh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Anavex. Dr. Sabbagh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. Dr. Sabbagh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cognito Therapeutics. Dr. Sabbagh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GSK. Dr. Sabbagh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Sabbagh has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for CervoMed. Dr. Sabbagh has stock in Neurotau. Dr. Sabbagh has stock in Seq Biomarque. Dr. Sabbagh has stock in uMethod Health. Dr. Sabbagh has stock in Athira. Dr. Sabbagh has stock in Lighthouse Pharmaceuticals. Dr. Sabbagh has stock in Alzheon. The institution of Dr. Sabbagh has received research support from NIH. The institution of Dr. Sabbagh has received research support from ADDF.
Cortexyme Appoints Marwan Sabbagh, MD, to its Board of Directors
Cortexyme, Inc., a clinical-stage biopharmaceutical company pioneering upstream therapeutic approaches to improve the lives of patients diagnosed with degenerative diseases, today announced the appointment of Marwan Noel Sabbagh, MD, FAAN, a board-certified neurologist and leading expert in Alzheimer’ s and dementia care, to the company’ s Board of...
(www.nasdaq.com)
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Ikke Anavex relateret direkte men dog alligevel.
En fantastisk historie om hans liv og hvor korrupte læger, store bio firmaer og FDA er.
Han lægger ikke fingrene imellem og nævner navne på firmaer og personer.
Det giver et rigtigt godt billede af den amerikanske bio industri, et meget trist billede, Anavex vil have svært ved at komme igennem uden en stor partner ingen trivl om det.Greed and the Pharmaceutical Industry-Ron Piana
Lavet af Soft White Underbelly som fortæller om hvad der er galt med USA, over 5.5 millioner abonnementer.
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Det amerikanske forskningsmiljø har klare forskelle til det danske når det handler om økonomi. Det mener jeg ikke nødvendigvis altid er diskvalificerende. Det er i hvert fald en præmis her. Jeg har en ret god fidus til videnskabelig redelig hos Novo Nordisk. Marwan Sabbagh var senest chair på deres AAIC sponserede konference for under 14 dage side. Hvis NN har tillid til Sabbagh - så vil jeg i udgangspunktet også ?
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Tak for en god men uhyggelig video med en klam fortælling Kyed01.
Han fortæller vel i bund og grund det vi alle vidste og frygtede.
Big pharma har hånden helt oppe i røven af FDA. Og lige meget hvor dygtige læger der findes er der desværre altid nogen der fristes og kan købes for penge.
En ting er at stjæle og snyde raske mennesker. Men at snyde død syge mennesker og lade dem tro at de får et middel der virker, men som istedet er placebo med forfærdelige bivirkninger er noget af det klammeste og laveste der findes.
Disse mennesker og big pharma er total uden skrubler og skyr alle midler.Jeg håber og tror ikke dette er tilfældet hos Anavex. Men i bund og grund så aner vi ikke hvilke firmaer der snyder.
Man kan kun følge sin mavefornemnelse og håbe på det bedste. Især for de stakkels patienter, som jo altså også er forsøgsdyr i alt det her. -
Utroligt hvad man kan blive belønnet for i Biotech (nyhed fra 8. August)
Cassava Sciences (NASDAQ: SAVA) ended its defamation lawsuit against four short sellers who questioned the validity of research supporting its Alzheimer's drug, simufilam. This decision comes after Hoau-Yan Wang, a medical professor whose research was crucial for the drug, was charged with fraud for submitting false data to the National Institutes of Health. Cassava's CEO and another executive resigned in July, and the new management decided to drop the lawsuit, calling it an "unnecessary distraction" from their mission to develop an Alzheimer's treatment. Shares closed up 21% at $35.08.
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Update fra Mayomobile
https://www.sotcanalytics.com/update-compendium-2024
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