Biotek-snakken — Juni 2021
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Fantastisk hvis Sutro kan hente sådan en deal. De nyeste data på MORAb-202, som jeg kan finde, er disse: https://clincancerres.aacrjournals.org/content/early/2021/06/03/1078-0432.CCR-20-4740 Response-raten ser god ud, men liver tox og ILD i 23% af patienterne?
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Det er desuden på FRalpha+ patienter, mener ikke Sutro selekterede på det i dose escalation? Samtidig kunne Sutros patienter godt tænkes i endnu højere grad at være heavily pre-treated, da MORAb-202 er testet på patienter der "bare" har fejlet på standard på standard therapy (https://meetinglibrary.asco.org/record/175229/abstract)
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Fin oversigt over situationen for FRalpha companies: https://www.evaluate.com/vantage/articles/news/deals/after-immunogen-and-sutro-bristol-buys-folate-story
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Entasis: Ny pre-clinical candidate etx0462 mod gram-negative infektioner, i alt 11 posters på World Microbe Forum 20-24.juni https://www.globenewswire.com/news-release/2021/06/18/2249593/0/en/Entasis-Therapeutics-Introduces-First-in-Class-Candidate-ETX0462-and-Presents-Data-on-SUL-DUR-and-ETX0282CPDP-at-World-Microbe-Forum.html Der står lidt mere om etx0462 på deres pipeline-side https://www.entasistx.com/pipeline
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The overall response rate (ORR) was 45.5% (10/22 pts) with 1 complete response (CR) (ovarian) at 0.9 mg/kg and 9 partial responses (PRs) at 0.68 mg/kg (1 TNBC, 1 ovarian and 2 NSCLC), 0.9 mg/kg (2 ovarian), 1.2 mg/kg (2 ovarian) and 0.3 mg/kg (1 endometrial). ORR of ovarian at ≥ 0.9 mg/kg was 71.4% (5/7 pts). The disease control rate (CR+PR+stable disease) was 81.8% (18/22 pts).
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ViewPoints: BMS pays a premium to get in on the ADC game
(Ref: ViewPoints Desk)
June 20th, 2021
By: Simon King
Tags: ViewPoints MORAb-202 BMS Eisai LicensingShare
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Last week’s deal with Eisai shows that antibody drug conjugates are not only compelling assets but Big Pharma is willing to pay handsomely for them.What's new?
Bristol Myers Squibb has paid $650 million upfront to co-develop Eisai's Phase I antibody-drug conjugate (ADC) MORAb-202. The deal could be worth up to $3 bill
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God morgen.
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Langers Skarpe: Hvor skal man søge ly for rentespøgelset? https://www.proinvestor.com/investornyt/676226/langers-skarpe-hvor-skal-man-soge-ly-for-rentespogelset
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