Biotek-snakken — Marts 2021
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Var der ikke lige nogen som droppede en FRa trial, kommende partner ? Vi skal vel også have bevis på at STRO-002 faktisk virker på FRa medium og high ved escalation data i 1H2020. Måske er der "bare" en immune effekt ? Tror du ikke vi skal have expansion data før der udlicensering sker, altså 2H2020 ?
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Den skal vel kombineres med en PD-1 inhibitor, jf. sidste års AACR: https://www.adcreview.com/news/preclinical-data-suggests-synergy-between-stro-002-and-immune-checkpoint-inhibitors-resulting-in-tumor-regression-and-adaptive-anti-tumor-immunity/. Den gang sagde de endda "We currently expect to initiate an STRO-002 combination clinical trial in 2021"
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Så spændende om en combination partner også vil overtage rettigheder til STRO-002
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Ja tak Lassevedel96, det vil vi gerne have noget mere af . These data suggest that STRO-002 can drive immune-modulatory responses that can cause complete tumor regression, tumor-specific T-cell activation, and adaptive anti-tumor immunity,” noted Sutro’s Chief Scientific Officer, Trevor Hallam, Ph.D
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Og timing på com
bination study er yderligere præciseret til 2021H2 i deres corporate presentation: https://www.sutrobio.com/wp-content/uploads/2020/12/SutroBiopharma_March-2021-vFINAL.01-compressed.pdf -
STRO-002 + Keytruda + Cytokine derivative ville godt nok være en drømmekombination! Jeg kan ikke huske om jeg tidligere har postet, men i Mercks Q4 presentation er Sutro angivet som en af Mercks vigtige oncology partners på slide 18 (for øvrigt sammen med Moderna, Eisai, Seagen og AstraZeneca, så fint selskab
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Derudover markedsfører Merck jo også Lynparza i ovarian cancer sammen med AstraZeneca, det er måske endnu en kombinationsmulighed
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