Genmab — December 2025
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RedirecTT-1 Talquetamab (GPRC5D) + Teclistamab (BCMA) - Dual Targeting of Extramedullary Myeloma with Talquetamab and Teclistamab - https://www.nejm.org/doi/full/10.1056/NEJMoa2514752 https://x.com/DrRishabhOnco/status/1997930035827929089
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for those that didn't read genmab's press release, the FL data was also published in the Lancet - Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1): a global, open-label, randomised, phase 3 trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02360-8/fulltext
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Genmab Announces New Data from Phase 1b/2 EPCORE
CLL-1 Highlighting Potential of Epcoritamab as Monotherapy and in Combination for Patients with Richter Transformation (RT) https://proinvestor.com/investornyt/1391260/genmab-announces-new-data-from-phase-1b-2-epcore-cll-1-highlighting-potential-of-epcoritamab-as-monotherapy-and-in-combination-for-patients-with-richter-transformation-rt -
Genmabs kræftmiddel viser opmuntrende resultater mod Richter transformation https://proinvestor.com/investornyt/1391335/genmabs-kraeftmiddel-viser-opmuntrende-resultater-mod-richter-transformation
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#ASH25 | PRESENTATION
Philip Thompson,
@MDAndersonNews@PeterMacCC
, presents first results of epcoritamab + lenalidomide (Arm 2B; N = 11) and epcoritamab + R-CHOP (Arm 2C; N = 30) in patients with Richter transformation from the phase Ib/II EPCORE CLL-1 trial. https://x.com/lymphomahub/status/1998150848279609470 -
ASH: J&J makes case for Tecvayli combo as an alternative to CAR-T in 2nd-line multiple myeloma https://www.fiercepharma.com/pharma/jj-makes-case-tecvayli-combo-alternative-car-t-second-line-multiple-myeloma
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Unprecedented results from the Phase 3 MajesTEC-3 study support TECVAYLI
plus DARZALEX FASPRO as a potential standard of care as early as second line for patients with relapsed/refractory multiple myeloma https://www.prnewswire.com/news-releases/unprecedented-results-from-the-phase-3-majestec-3-study-support-tecvayli-plus-darzalex-faspro-as-a-potential-standard-of-care-as-early-as-second-line-for-patients-with-relapsedrefractory-multiple-myeloma-302636559.html?tc=eml_cleartime -
NEJM -
Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma https://www.nejm.org/doi/full/10.1056/NEJMoa2514663 -
"The Company has submitted a supplemental Biologics License Application (sBLA) for the use of TECVAYLI
and DARZALEX FASPRO in combination as a treatment for RRMM to the U.S. Food and Drug Administration (FDA). The FDA has granted Breakthrough Therapy Designation (BTD) for the combination regimen"
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