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  4. Genmab — Juli 2025

Genmab — Juli 2025

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #145

    A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade https://www.nature.com/articles/s41598-025-11990-z

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    • G Offline
      G Offline
      gentogen
      wrote on sidst redigeret af
      #146

      The study of this was terminated prior to the start of the Dose Expansion Phase.NCT05435339. Many positive things in the article, but I kind of lack a coclusion about the development as ended or not?

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #147

        They discontinued the clinical development.

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #148

          this is what it said last august24: Following a strategic evaluation of GEN1053 within the context of
          Genmab’s and BioNTech’s portfolios, a decision was made to discontinue the Phase 1/2 clinical trial
          (NCT05435339) of GEN1053 in solid tumors. Preclinical activities remain ongoing.

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #149

            whether those preclinical activities aim to return with something on Hexabody-CD27 I don't know (but i doubt it). Maybe it is to get more info on the Hexabody technology

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #150

              But both Özlem Türeci & Uğur Şahin from biontech co-authored it, so they must have deemed it of interest

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              • G Offline
                G Offline
                gentogen
                wrote on sidst redigeret af
                #151

                Thanks a lot for the extra info.

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                • Helge_LarsenPI-redaktørH Offline
                  Helge_LarsenPI-redaktørH Offline
                  Helge_LarsenPI-redaktør
                  wrote on sidst redigeret af
                  #152

                  Godmorgen 🙂

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                  • S Offline
                    S Offline
                    Stroka
                    wrote on sidst redigeret af
                    #153

                    God morgen 🙂

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                    • P Offline
                      P Offline
                      ProinvestorNEWS
                      wrote on sidst redigeret af
                      #154

                      Genmab Transcript Special Call: Ser Rina-S i markedet i 2027 med peak-salg på 2 mia. USD https://proinvestor.com/investornyt/1343403/genmab-transcript-special-call-ser-rina-s-i-markedet-i-2027-med-peak-salg-pa-2-mia-usd

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                      • BulderB Offline
                        BulderB Offline
                        Bulder
                        wrote on sidst redigeret af
                        #155

                        Tak til ØU for fremskaffelse og udarbejdelse af fortrinligt materiale.

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #156

                          ESMO 2025 Industry Satellite Symposium

                          Genmab - Advancing Antibody-Drug Conjugates Into the Future of Gynecologic Malignancies https://cslide.ctimeetingtech.com/esmo2025/attendee/confcal/session/calendar?q=genmab

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #157

                            ESMO 2025 1121P - Rinatabart sesutecan (Rina-S®) for patients with advanced or recurrent endometrial cancer (a/r EC): Update from dose expansion cohort B2 of RAINFOL™-01

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                            • E Offline
                              E Offline
                              E_L
                              wrote on sidst redigeret af
                              #158

                              ESMO 2025 1166P - Tisotumab Vedotin Plus Carboplatin or Pembrolizumab in Recurrent or Metastatic Cervical Cancer: 5-Year Results From the innovaTV 205/GOG-3024/ENGOT-cx8 Study

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                              • P Offline
                                P Offline
                                ProinvestorNEWS
                                wrote on sidst redigeret af
                                #159

                                Teknisk: Genmab bryder op gennem 200 MA, mere i vente mandag https://proinvestor.com/investornyt/1343407/teknisk-genmab-bryder-op-gennem-200-ma-mere-i-vente-mandag

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                                • P Offline
                                  P Offline
                                  ProinvestorNEWS
                                  wrote on sidst redigeret af
                                  #160

                                  Ugens danske Vindere & Tabere: Endelig en super-uge for dansk life science https://proinvestor.com/investornyt/1343406/ugens-danske-vindere-amp-tabere-endelig-en-super-uge-for-dansk-life-science

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                                  • DarvinD Offline
                                    DarvinD Offline
                                    Darvin
                                    wrote on sidst redigeret af
                                    #161

                                    Spændende og bekræftende læsning. Og så skal man skrive sig bag øret, at de 2 mia $ kun er i onkologi. Som de angiver virker det sandsynligt, at Rina-S også virker i andre solide kræftformer. Altså er de 2 mis måske slet ikke i nærheden af et muligt topsalg.

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                                    • B Offline
                                      B Offline
                                      bikube
                                      wrote on sidst redigeret af
                                      #162

                                      Rigtig flot transcript. Jeg synes dog, at Tahi kommer lidt let henover "Two fatal AE´s in 120Mg", men det var jo nok en del af grunden til kun at fortsætte med 100 Mg.

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                                      • L Offline
                                        L Offline
                                        lahn1
                                        wrote on sidst redigeret af
                                        #163

                                        Bikube, det er de samme 2 AE som blev nævnt i post ASCO præsentationen d. 2 juni. Hvor analytikkerne også spurgte ind til det. En pt havde mange comorbidities og døde as septic shock og den andens død blev ikke bedømt at være grundet Rina-S. Se side 12 . https://genmab-2025-post-asco-virtual-rd-update-june25.open-exchange.net/replay

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                                        • L Offline
                                          L Offline
                                          lahn1
                                          wrote on sidst redigeret af
                                          #164

                                          Hov det var videon. Her er præsentation. https://ir.genmab.com/static-files/da696dd4-c1be-4903-83b9-99b73bba55c8

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