Genmab — April 2025

[concillado]

Genmab A/S Share Capital Reduction.. hvad er jeres holdning/erfaring med dette?

[bikube]

Det var da et smukt træk, lige at slette et par millioner aktier. og opkøbet kører videre til juli.

[wisuwa]

Med lidt hurtig hovedregning er det ca. 1% af aktierne, no?

[wisuwa]

Hvor mange % kan vi regne med at reducere via denne omgang aktietilbagekøb?

[bikube]

Dagens sletning er fra ca. 66,3 Mio til 64,12, det må være ca 1½%

[bikube]

De har stadig over en Mio aktier på lager, og der forventes opkøbt ca 1½ Mio mere i det her opkøb.

[Solsen]

Det er vel ca 3%

[wisuwa]

Haha jo, du har ret. 3%. Har ikke fået min aftenkaffe i dag…

[bikube]

Og jeg er udgået for logisk tænkning. I går faldt VIXen fra 50 til 30 ca. nu er den oppe i 47. Geniet er stabilt.

[E_L]

article in Blood - Epcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial https://ashpublications.org/blood/article/doi/10.1182/blood.2024026830/535030/Epcoritamab-plus-GemOx-in-transplant-ineligible

[gentogen]

Imponerende. ORR and CR rate were 85% and 61%, respectively ( i patienter der ikke har mange muligheder)

[E_L]

No­var­tis fol­lows Lil­ly and J&J in an­nounc­ing multi­bil­lion-dol­lar US man­u­fac­tur­ing in­vest­ment -
With US tar­iffs on phar­ma­ceu­ti­cals like­ly to come "very soon," an­oth­er of the world's largest drug­mak­ers is an­nounc­ing plans to beef up their Amer­i­can man­u­fac­tur­ing.

[E_L]

On Thurs­day, Swiss-based No­var­tis said it would in­vest $23 bil­lion in Amer­i­can man­u­fac­tur­ing and R&D over the next five years. It fol­lows sim­i­lar moves this year by In­di­anapo­lis-based Eli Lil­ly and New Jer­sey-head­quar­tered John­son & John­son.

[E_L]

As part of No­var­tis' in­vest­ment, which in­cludes sev­en new fa­cil­i­ties, the com­pa­ny said it will be able to make all of its "key" med­i­cines "end-to-end" in the US. It was­n't im­me­di­ate­ly clear how the com­pa­ny was defin­ing "key" drugs, and if that meant some med­i­cines it sells in the US will still be man­u­fac­tured else­where.

[lahn1]

Hvem skal man investere i for at få nytte af alle de fabrik opførelser ? Hvem laver produktionslinjerne ?

[GUHO]

I første omgang tænker jeg arkitekter, rådgivere og entreprenører indenfor byg og anlæg. Det marked burde have svære tider på grund af rentehoppet, men har enorm efterspørgsel på grund af Novos fabriksudvidelser

[E_L]

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects https://jitc.bmj.com/content/13/4/e011377

[lahn1]

EL is Genmab here telling more than they have previous told about moa and Acasunlimab. They were previously very secretly and would not tell too much for competitive reasons.

[E_L]

I see it as a deepening of understanding of the concept we have been shown before; more detailed and with actual data i don't think we have seen anywhere yet. It is a further explanation of why they think this works , based on pre-clinical work.

[E_L]

i think it also explains a bit more how the effect of Acasunlimab is mainly directed at the tumor microenvironment, minimizing broader effects (as we have seen in the clinical data where there was hardly any liver toxicity)
The proof will be in the actual trial data of course...