Genmab — December 2024
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small new University trial- Epcoritamab and Lenalidomide in Treating Patients With Refractory or Relapsed Immunodeficiency-Related Large B-Cell Lymphoma https://clinicaltrials.gov/study/NCT06723457
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Det tror jeg ikke: Under our agreement with Janssen, Genmab is eligible to receive milestones and receives royalties between 8% and 10% on net sales of RYBREVANT, a mid-single digit royalty on net sales of TECVAYLI, and a mid-single digit royalty on net sales of TALVEY, all of which are subject to a reduction of such royalty payment in countries and territories where there are no relevant patents (as defined in the agreement), among other reductions.
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Sukkeralf, det er oplyst flere gange på konferencer etc. Derfor forskellen på royalty procent I forhold til Rybrevant.
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"The unprecedented durability of response seen in these data reinforce the potential of epcoritamab to become a core therapy for the treatment of multiple B-cell malignancies to benefit more patients," said Dr. Judith Klimovsky https://ml-eu.globenewswire.com/Resource/Download/5d2ab26b-5092-40d5-85c9-b653ab612acd
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same from AbbVie
"More first-line treatments for diffuse large B-cell lymphoma are needed, especially for patients with aggressive disease markers that may impact the efficacy of current standard first-line therapies," said Lorenzo Falchi, M.D., Lymphoma Specialist, Department of Medicine, Memorial Sloan Kettering Cancer Center. "The durable responses observed in the study suggest significant potential for this first-line epcoritamab-based combination." -
Two Data Analyses From Clinical Trials Show Epcoritamab (DuoBody® CD3xCD20) Induces Durable Complete Reponses As Monotherapy and Combination Treatment in Patients With Diffuse Large B-Cell Lymphoma
Data presented at the 66th Annual Meeting and Exposition of the American Society of Hematology (ASH) NORTH CHICAGO, Ill., Dec. 9, 2024 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced new...
AbbVie News Center (news.abbvie.com)
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Genmab har mandag offentliggjort positive langsigtede data fra to igangværende kliniske forsøg med antistoffet Epcoritamab til behandling af diffust storcellet B-celle lymfom.
Det fremgår af en meddelelse til fondsbørsen mandag aften.https://borsen.dk/nyheder/virksomheder/genmab-leverer-igen-lovende-data-fra-kraefthab?b_source=borsen&b_medium=row_0&b_campaign=list_1
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Tak for den skarpe analyse nohope
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Thomas Bowers fra Danske skifter til SEB. Ham har jeg nu alle dage synes godt om. Forhåbentlig fortsætter han sit syn på Genmab i den nye rolle. https://www.linkedin.com/posts/thomas-bowers-36394b4_jeg-er-glad-for-at-kunne-dele-at-jeg-starter-activity-7268918631357431808-ppx2?utm_source=share&utm_medium=member_android
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AbbVie, Genmab tout Epkinly combos in earlier lines of non-Hodgkin lymphoma https://endpts.com/ash24-abbvie-genmab-tout-epkinly-combination-in-earlier-lines-of-non-hodgkin-lymphoma/
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"Epkinly plus R-CHOP is being tested in an ongoing Phase 3 trial in the first-line setting. Allam Fakhoury, AbbVie’s therapeutic area lead in hematology oncology, told Endpoints News that the Phase 3 study in DLBCL is fully enrolled, and the company is “evaluating when the readout will be.” "
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Epcoritamab + R-CHOP overcomes high total metabolic tumor volume in high-risk large B-cell lymphoma https://www.youtube.com/watch?v=bTNyW_82_Ks
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0:15 / 1:07
Evaluating whether prior bendamustine exposure impacts the efficacy of epcoritamab in DLBCL https://www.youtube.com/watch?v=MFJdK1oXTns
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@calliecoombsmd
Much lower severity CRS when using optimized schedule of epcoritamab and with promising response data - high rates of CR and uMRD! Median PFS 12.8 months. https://x.com/calliecoombsmd/status/1866254711781028086
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