Genmab — September 2024
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@Sukkeralf kl.21.33 - Når Jan siger sådan, så er det jo også sådan det er. - Set fra mit synspunkt bliver Jan da kun mere troværdig, ved at fortælle at der skal altså noget ekstraordinært til at overbevise JnJ ift. CD38..... Men alligevel er han meget fortrøstningsfuld ift at JnJ nok skal opte ind....... Hvis han følte sig det mindste i tvivl, så vil i min verden have en helt anden approach...
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Selv om ventetiden er lang, så synes jeg egentlig, at det er meget klogt at Jan ikke belyser Genmabs HEXACD38 planer (ved opt ud) nu, altså før data foreligger. Den lektie har Jan lært. Sådan set giver han bare en stribe argumenter for, at HEXA ligger perfekt til JNJ. og så slut.
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Måske fordi alternativet er pinligt ringe ? Uden opt i fra JNJ så er Hexa tæt på værdiløst? Det er udelukket fra at blive udviklet til hovedformålet og kan måske bruges perifert til andre formål - anvendelser der end ikke kan dække omkostningerne til at udvikle/opnå godkendelse.
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we don't know that yet. maybe it has a future in solid tumors if no steroids are needed. or autoimmune diseases, where we have already seen how Dara can be effective. We al remember possibilities for CD38 in rheumatoid arthritis. I would think Genmab has a fairly good idea of possible alternative routes, even though they have not made it public
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Her er jeg også ret overbevist om at der er en plan B.... og vil give @gentogen ret - der er ingen god grund til at forvirre markedet mere end det tilsyneladende er.... Som det er nu er det temmelig sort og hvidt opt ind eller ud?..... Når det er sagt, så føler jeg at plan B er nærmest ikke eksisterende i Jan's sind...
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TRANSCRIPT
JNJ.N - Johnson & Johnson at Morgan Stanley Global Healthcare
Conference
https://s203.q4cdn.com/636242992/files/doc_downloads/2024/09/jnj-usq_transcript_2024-09-04.pdf -
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Godmorgen
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EL 11.22 I clearly assume that Genmab already has a plan B ready if CD38 is not selected by JJ. They've definitely already looked into it. And - yes, it could be, for example, Rheumatoid arthritis, or other autoimmune diseases, which is an extremely large target. But could also be completely different indications. with regard to Rheumatoid arthritis, there are, by the
way, a great many co-morbidities linked to it. -
New longer-term data from the MARIPOSA study confirm superior outcomes of chemotherapy-free RYBREVANT
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