Genmab — Maj 2024
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Børsen gentager verdens 10 bedst sælgende lægemidler. 3. Ozempic 14 mia. USD, 10. Darzalex 9,7 mia. USD https://borsen.dk/nyheder/virksomheder/se-listen-novo-storsaellert-blandt-de-bedst-saelgende-i-verden?b_source=borsen&b_medium=row_0&b_campaign=list_1
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Med hensyn til spørgsmålene i går om Hexa38, så er bedste kilde indtil videre vist nok statig artiklen fra the Lancet: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00228-1/fulltext
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We’re advancing our DuoBody
platform technology with the goal to unlock the potential of #bispecific antibody research, as we work to transform how cancer is treated. Watch the video below to learn more about our technology. #ASCO24" https://x.com/Genmab/status/1796542979273809922?t=SBZtpWL3ba-xUGouEiqH3Q&s=19 -
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Enhanced CDC: Hexabody-CD38 is engineered to enhance complement-dependent cytotoxicity (CDC) through hexamerization. This increased CDC activity can overcome the reduced sensitivity to complement-mediated lysis seen in DARA-resistant patients due to the upregulation of complement inhibitory proteins (CD55 and CD59).
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Broader Mechanisms: Hexabody-CD38 not only enhances CDC but also maintains other mechanisms of action such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and apoptosis induction. These multiple mechanisms provide a robust anti-tumor activity, which is beneficial for overcoming resistance
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No Inhibition by Preincubation with DARA: Preclinical studies indicate that preincubation with DARA does not inhibit Hexabody-CD38 from reaching its full capacity to induce CDC, suggesting that Hexabody-CD38 can still be effective even if DARA has been used previously.
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In Vivo and Ex Vivo Efficacy: Hexabody-CD38 has demonstrated strong anti-tumor activity in patient-derived xenograft (PDX) models and primary MM cells, including those from DARA-refractory patients, indicating its potential effectiveness in a clinical setting.
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In summary, the combination of enhanced CDC, robust multi-faceted mechanisms of action, effectiveness in lower CD38 expression levels, and promising preclinical results all suggest that Hexabody-CD38 should help patients who are resistant to Darzalex. The ongoing clinical trials will provide further validation of its safety and efficacy in this patient population.
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ASCO LBA out: Subcutaneous amivantamab vs intravenous amivantamab https://meetings.asco.org/abstracts-presentations/232405 . seems like a slam dunk.
ja ja ved godt det nok ikke holder i virkeligheden. men her er hvad Chat GPT 4.0 siger om emnet i bullet points
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