Genmab — Oktober 2023
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SITC Abstract 813- Combination of HexaBody-CD27 with PD-(L)1 blockade potentiates single-agent activity leading to enhanced human T-cell effector functions in vitro https://jitc.bmj.com/content/11/Suppl_1/912
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SITC23 Abstract 1181- GEN1042-mIgG2a, an Fc-inert mouse-human chimeric variant of GEN1042 (DuoBody
-CD40x4-1BB), exhibits in vivo antitumor activity and peripheral immune modulation https://jitc.bmj.com/content/11/Suppl_1/1302 -
SITC23
681- innovaTV 207 Parts E and F: A phase 2 study of tisotumab vedotin in patients with head and neck squamous cell carcinoma (trial in progress) https://jitc.bmj.com/content/11/Suppl_1/772 -
Tepezza sales not yet included in the Amgen sales, but discussed in the call Q3 '23 -In the third quarter, sales of Tepezza reached $453 million, the company said on Tuesday. While Amgen was quick to point out that it was a 2% increase from the previous quarter, it also was an 8% decline year over year. Amgen has a plan to get Tepezza’s groove back, using a playbook that the company employed with vasculitis drug Tavneos after its 2020 acquisition of Chemocentryx.
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https://www.irishtimes.com/business/2023/10/25/irish-jobs-to-go-as-amgen-cuts-350-horizon-employees-after-takeover/ Detvar så kun ca 20% de fyrede. Men lidt omstilling vil koste på omsætningen kortvarigt må man vel forvente. Spændende hvad den store organisation kan gøre ved Tapezza.
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Jeg fandt lige følgende fra Handelsbanken dateret oktober 2022 angående Hexabody CD38 »For indeværende indikerer de prækliniske data for Hexabody-CD38, at antistoffet er ti gange mere potent end Darzalex, om end sikkerhedsprofilen endnu ikke er bekræftet. Endelige forsøgsdata vil blive offentliggjort i de kommende 12-18 måneder,« skriver Handelsbanken i sit morgenbrev. Har vi ikke hørt yderligere det seneste år.?
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Der er denne artikel fra juni, men resultater fra klinikken holder de tæt til kroppen: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00228-1/fulltext
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