Genmab — Februar 2023
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I started 01.01.2023,
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For the first time, we report a successful approach to the treatment of refractory anti-NMDAR encephalitis
using the fully human anti-CD20 monoclonal antibody ofatumumab, which serves as an important
reference for the treatment of autoimmune encephalitis. In our cases, satisfactory clinical outcomes were still observed in anti-NMDR encephalitis
while first-line therapy failed. Thus, the case report provides reference for new treatment options of
autoimmune encephalitis -
Our Alem-Ofa dual-targeted immunotherapy study showed that it is an early example of a chemotherapy-free treatment option with several advantages even in the modern treatment era. First the treatment is of a limited and short duration of no longer than 4.5 months. Second, it was able to achieve rapid onset, deep and durable response; most patients needed no additional therapy in the next five years.
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Tak gentogen. Hjernebetændelse rammer 250.000 hvert år alene i usa https://www.hopkinsmedicine.org/health/conditions-and-diseases/encephalitis
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