Genmab — November 2022

[E_L]

and from Mathai Mammen, when he was still at JNJ, -This study with the HexaBody is being run by Genmab in close collaboration with us. And it's a next generation even more effective CD38 blocker, deep activity on CD38 positive cells. And we'll see data towards the end of this year that'll help us understand whether there's a path forward, both in multiple myeloma, by the way, and diffuse large cell B cell lymphoma. And so, this is exciting for us.

[Legolas23]

Hvornår er bagkanten LBA ? Kunne vi ikke få en overraskelse med der?

[E_L]

recommended phase 2 dose is established -primary objective of the trial-, but -to me most important- safety seems manageable, which was the biggest fear Jan had in the past

[E_L]

Looks a bit like Dara, with mainly 1st infusion related reactions?

[E_L]

However: 'Disease progression led to discontinuation in 80% of pts.' not sure what to make of that

[E_L]

Is it the first time we hear about GEN3017 (DuoBody-CD3xCD30)?

[E_L]

ASH 1366 Duobody-CD3xCD30 Demonstrates Potent Anti-Tumor Activity in Preclinical Models of CD30+ Hematologic Malignancies https://ash.confex.com/ash/2022/webprogram/Paper159396.html

[Solsen]

7 prior cycles makes it very difficult pts to treat.

[Solsen]

Its difficult to judge on 19 such pts and many with low conc. drug.

[E_L]

absolutely. safety is what it is all about at this stage for me. and we'll see a bit more data at the conference in december

[E_L]

ASH 611 Subcutaneous Epcoritamab in Combination with Rituximab + Lenalidomide (R2) for First-Line Treatment of Follicular Lymphoma: Initial Results from Phase 1/2 Trial https://ash.confex.com/ash/2022/webprogram/Paper158232.html the overall response rate was 90% (26/29), with 69% (20/29) having a complete metabolic response (CMR) as their best overall response.

[E_L]

ASH 609 Subcutaneous Epcoritamab with Rituximab + Lenalidomide in Patients with Relapsed or Refractory Follicular Lymphoma:Phase 1/2 Trial Update - https://ash.confex.com/ash/2022/webprogram/Paper158203.html - the overall response rate was 95% (39/41), with 73% of patients (30/41) achieving a complete metabolic response (CMR) as their best overall response -Slightly higher as before

[E_L]

ASH 443 Subcutaneous Epcoritamab + R-Dhax/C in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma Eligible for Autologous Stem Cell Transplant: Updated Phase 1/2 Results - https://ash.confex.com/ash/2022/webprogram/Paper158278.html

[E_L]

ASH 348 Subcutaneous Epcoritamab in Patients with Richter’s Syndrome: Early Results from Phase 1b/2 Trial (EPCORE CLL-1) - https://ash.confex.com/ash/2022/webprogram/Paper158298.html

[E_L]

2 posters for Camidanlumab https://ir.adctherapeutics.com/press-releases/press-release-details/2022/ADC-Therapeutics-Announces-Abstracts-Accepted-for-Presentation-at-the-64th-ASH-Annual-Meeting/default.aspx

[Solsen]

Jeg har lidt AFMD, der kom med flere nyheder i dag. https://finance.yahoo.com/news/affimed-announces-presentation-phase-1-130500953.html Måske kunne nogen have lidt interesse i den. På eget ansvar

[Solsen]

Hold nu op hvor er jeg en glad Genmab aktionær. Dette år har slet ikke givet de skrammer, som mange aktionærer oplever i år. Lad det fortsætte

[gdn55]

Ligeså her Solsen. Har været i tvivl mange gange de sidste ca. 20 år, men har heldigvis holdt ved.

[Helge_LarsenPI-redaktør]

Kort video: I den sidste uges tid er det væltet ind med q3-regnskaber, bl.a. fra Danske Bank og Novo Nordisk. Derudover kommer Helge Larsen ind på Eli Lilly, Zealand Pharma og Bavarian Nordic - sidstnævnte især omhandlende shorting.https://www.proinvestor.com/boards/107506

[E_L]

if you see the performance of some other biotechs, we should indeed be lucky with genmab... Today Merus -24% again, Genmab's neighbour in Utrecht....