Bavarian Nordic — September 2017
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Based on patients’ ratings of their pain, the effect of trialled drugs in relieving symptoms stayed the same over the 23-year period—but placebo responses rose. In 1996, patients in clinical trials reported that drugs relieved their pain by 27% more than did a placebo. But by 2013, that gap had slipped to just 9%. The phenomenon is driven by 35 US trials; among trials in Europe, Asia and elsewhere, there was no significant change in placebo reponses.The analysis is in press in the journal Pain.
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Novod siger spændende data -
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Nordea: So unless the placebo/control group ends up performing vastlydifferently than in recent trials with Xtandi and Ipilimumab, OS could be significantly increased with PROSTVAC. We are cautious in drawing too firm conclusions, but we find Dr Gulley’s presentation intriguing ahead of the final PROSTVAC ph III read-out.
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Dette må være et godt tegn, så vi kan sove roligere indtil de endelige resultater. Ingen markant reaktion på markedet. Shorterne må da blive lidt bekymrede over di
sse data -
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Vel ikke overrakskende at der er et fald i receptudskrivelserne i industriferien?
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godt. Så er vi enige.
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bemaerk at den samlede overlevelseskurve er stort set vandret fra måned 50 til 65. Der er jo - som tidligere fortalt - stort set ingen der doer. Ca 23-24 % synes at leve sygdommen. Fortsaetter denne udvikling vil det blive rigtig stort.
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Kurt - pas på med at blive for optimistisk. Tænk på at standardbehandlingen har forbedrets markant siden Xtandis godkendelse. Så placebogruppen klarer sig derfor også bedre end tidligere. Jeg vil bare mane til lidt forsigtighed!
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Enig Sukker.
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Det vil sige at reelt set så skal forsøget vise hvorvidt Prostvac er overlegen i forhold til Xtandi eller er denne kun standard behandling i nogle af regionerne .... givet at der ikke er forskel i OS i de to arme er det i så fald ikke nødvendigvis dårligt nyt men blot en verificering af at prostvac matcher Xtandi... eller overser jeg noget her?
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