Bavarian Nordic — Februar 2016
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Så gik IBB i +, var tidligere nede med over 2%
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God morgen.
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Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice
Poxvirus-based active immunotherapies mediate anti-tumor efficacy by triggering broad and durable Th1 dominated T cell responses against the tumor. While monotherapy significantly delays tumor growth, it often does not lead to complete tumor regression. It was hypothesized that the induced robust infiltration of IFNγ-producing T cells into the tumor could provoke an adaptive immune evasive response by the tumor through the upregulation of PD-L1 expression. In therapeutic CT26-HER-2 tumor models, MVA-BN-HER2 poxvirus immunotherapy resulted in significant tumor growth delay accompanied by a robust, tumor-infiltrating T cell response that was characterized by low to mid-levels of PD-1 expression on T cells. As hypothesized, this response was countered by significantly increased PD-L1 expression on the tumor and, unexpectedly, also on infiltrating T cells. Synergistic benefit of anti-tumor therapy was observed when MVA-BN-HER2 immunotherapy was combined with PD-1 immune checkpoint blockade. Interestingly, PD-1 blockade stimulated a second immune checkpoint molecule, LAG-3, to be expressed on T cells. Combining MVA-BN-HER2 immunotherapy with dual PD-1 plus LAG-3 blockade resulted in comprehensive tumor regression in all mice treated with the triple combination therapy. Subsequent rejection of tumors lacking the HER-2 antigen by treatment-responsive mice without further therapy six months after the original challenge demonstrated long lasting memory and suggested that effective T cell immunity to novel, non-targeted tumor antigens (antigen spread) had occurred. These data support the clinical investigation of this triple therapy regimen, especially in cancer patients harboring PD-L1neg/low tumors unlikely to benefit from immune checkpoint blockade alone.
(journals.plos.org)
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math - MVA-BN tilhører Bavarian. BN står for Bavarian Nordic. Så ja, ser godt ud
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Postate Cancer market to reach USD 13,6 Billion http://www.euroinvestor.dk/redirect.aspx?https%3A%2F%2Fwww.newswire.com%2Fnews%2Fprostate-cancer-market-to-reach-13-6-billion-revenue-growth-till-2021-8137555
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Prostvac nævnes først af nye medicamenter der kan komme i spil
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Enig OHW.
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På EI er der rygter om snarlig EU Imvamune ordre
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Ham der skriver "Mueller", er dygtig
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Bava: Er der nogen som kan byde ind her? http://www.proinvestor.com/debat/74338
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Tidsmæssigt passer sammen med offentliggørelse Prostvac fase 3, første interimsresultat. Og jeg pointerer, at Bavarian ikke kender resultatet, men kun tidspunkt for offentliggørelse. Men jeg gætter....
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BAVA 6,25% op i dag. Det kan da ikke kun være i sympati med Genmab. Zealand stiger jo "kun" 2%
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