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Genmab — Maj 2021

Planlagt Fastgjort Låst Flyttet Genmab
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Denne tråd er blevet slettet. Kun brugere med emne behandlings privilegier kan se den.
  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #557

    FL at doses ≥12 mg (n=5) was 80% (CR=60%; PR=20%) versus november data: (n=3); ORR 100% (CR=66.7%; PR=33.3%)

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #558

      I think that looks very very solid, with responses clearly deepening over time, PR’s converting to CR’s. No additional Aes. That treatment was ongoing in only 15 (22%) patients from the starting of the original 68 is unpleasant to read though, but this is in aggressive disease with patients heavily pretreated.

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #559

        I find the comparisson with Glofitamab a bit difficult, they are longer into the trial (27 months? vs 14 months). If i can compare Glofi DLBCL ORR of 41.1% (n = 30), with CR in 28.8% (n = 21). And FL ORR 55.2% and CR 34.5%, Epco clearly seems better?

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        • E Offline
          E Offline
          E_L
          wrote on sidst redigeret af
          #560

          It is rather annoying that EHA have embargoed some abstracts again, I copied this on Talquetamab yesterday:

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #561

            Conclusion

            Talquetamab, at the RP2D of weekly 405 μg/kg SC, demonstrated a high clinical response rate and was well-tolerated in patients with relapsed/refractory MM. Based on the pharmacokinetic data, other SC dosing strategies are also being explored. The promising efficacy and safety profile, and the convenience of SC dosing support monotherapy development and combination approaches with this novel agent.

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            • E Offline
              E Offline
              E_L
              wrote on sidst redigeret af
              #562

              I think AEs looked probably a bit high with some grade 3/4 neutropenia and anemia, but looking at above conclusion it looks as if they think they can improve that with a different dosing strategie

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #563

                Thx E L. Yes, the shift from PR to CR is impressing.

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #564

                  I suppose we'll soon see a filing of dara as maintenance.

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #565

                    Nice that you got the conclusion from Cass part 2 before they locked it up. 🙂

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                    • BulderB Offline
                      BulderB Offline
                      Bulder
                      wrote on sidst redigeret af
                      #566

                      Ser ud til at Dax'en lader sig inspirere af us-nedtur i går. Futterne dog ikke helt så røde.

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                      • G Offline
                        G Offline
                        GeorgeBest
                        wrote on sidst redigeret af
                        #567

                        11:39 agree E L, for me epco also looks best-in-class 🙂

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                        • G Offline
                          G Offline
                          GeorgeBest
                          wrote on sidst redigeret af
                          #568

                          we still to have wait to see if Glofi comes with a subcu version, but if not epco clearly looks like a potential winner

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                          • BulderB Offline
                            BulderB Offline
                            Bulder
                            wrote on sidst redigeret af
                            #569

                            On the safety-side epco clearly has the advantage of only making CRS grade 1 or 2, where glofi is associated with some cases of grade 3 and 4.

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                            • Legolas23L Offline
                              Legolas23L Offline
                              Legolas23
                              wrote on sidst redigeret af
                              #570

                              Der er vel også et økonomisk aspekt epco Vs Glofi ?

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #571

                                Dax'en ser ud til at rette sig efter at have været nede med 2% i formiddags. Nu minus 0,5%

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                                • BulderB Offline
                                  BulderB Offline
                                  Bulder
                                  wrote on sidst redigeret af
                                  #572

                                  Futterne begynder så småt at grønnes. Vix nede med 8%

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                                  • P Offline
                                    P Offline
                                    Plimsoller
                                    wrote on sidst redigeret af
                                    #573

                                    God morgen 🙂

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                                    • Helge_LarsenPI-redaktørH Offline
                                      Helge_LarsenPI-redaktørH Offline
                                      Helge_LarsenPI-redaktør
                                      wrote on sidst redigeret af
                                      #574

                                      God morgen. 🙂

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                                      • Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktørH Offline
                                        Helge_LarsenPI-redaktør
                                        wrote on sidst redigeret af
                                        #575

                                        Spørgsmål til Q&A er meget velkommen. 🙂

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                                        • Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktørH Offline
                                          Helge_LarsenPI-redaktør
                                          wrote on sidst redigeret af
                                          #576

                                          Udover Q&A mandag har Proinvestor
                                          sammen med Nordnet biotekwebinar med Genmab, Bavarian og Zealand Pharma tirsdag. Tlmelding: https://events.nordnet.dk/nordnet-events/kom-helt-taet-paa-tre-biotekvirksomheder-bavarian-zealand-pharma-genmab/

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