Genmab — December 2020
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Summary points from expert feedback:
Preliminary efficacy for BCMA-directed bispecifics ranging from 60% to 80% looks very promising
Risk/benefit profiles not mature enough to identify distinguishing features but too soon to rule out Amgen’s AMG 701 based on early safety data -
KOL sees bispecifics quickly being moving up as part of combinations as far as first relapse, and eventually perhaps even into first-line treatment
Anti-BCMA CAR-T cells will have an initial first-to-market advantage but bispecifics’ ease of use should give them a leg up, especially in the community
Candidates addressing novel targets like FcRH5 and GPCR5D look highly promising for BCMA-experienced patients -
Case Report: Daratumumab in a Patient With Severe Refractory Anti-NMDA Receptor Encephalitis https://www.frontiersin.org/articles/10.3389/fneur.2020.602102/full
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November Darzalex US salg $ 237M. (November havde 19 arbejdsdage mod 21 i oktober).
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10 % ?
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Så må vi se frem til den 20. februar!
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Rigtigt gode recepttal - usd 15m mere end mine estimater. Men det er nok de færre klinikdage, der driller markedet
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Den faldende dollar kurs betyder noget af et hak i tuden
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mht guidens for næste år
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