Genmab — December 2020

[Rondo]

Ja så banker vi lige på igen og ser om der er nogen der lukker op ....:-)

[E_L]

New Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma https://www.clinicaltrials.gov/ct2/show/NCT04663347

[Muldyr]

Døren smækkede i Rondo - men måske åbnes den igen ved luk...

[Rondo]

Ja den springer ikke op af sige selv......

[Vitus]

Men vi er da tæt på ....

[Rondo]

Ja....fik da lige næsen i klemme ....goo weekend.....

[Bulder]

Nice E L. Two of the arms are frontline.

[E_L]

Indeed! Very exciting, I didn't expect them to go for frontline already

[bibob]

E L. 130 participants. ?? Isn't a small number for frontline. ?

[bibob]

I have expected Maybe about 3- 400 . ?

[Bulder]

No, it's a phase 1/2. Quite normal.

[E_L]

It is still a Ph1/2 safety study, they may need bigger Ph3s
?

[E_L]

Snap lol

[bibob]

Ok. Thx.

[Bulder]

Yes they'll have to conduct a larger ph 3 for approval.

[bikube]

Dansk deltagelse i Århus, Vejle og Odense - så er Plesner på en ny opgave.

[E_L]

I think it will be the new Plessner, called Hutchings

[Solsen]

Think they could add more patient to the trial if they have evidence on success. And then make it a pivotal trial.

[Solsen]

DLBCL er en svær sygdom at få kontrol over. Selv om linket har nogle år på bagen så er der mange interessante resultater samlet https://ashpublications.org/hematology/article/2016/1/366/21001/Diffuse-large-B-cell-lymphoma-R-CHOP-failure-what

[Solsen]

Mon ikke Abbvie kører direkte i et stort fase 3 med Ibrutinib https://www.sciencedirect.com/science/article/abs/pii/S1040842820301487