Genmab — December 2020
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Optimal epco dose decided by efficacy - not toxicity
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Optimal dose 48mg only has n=12
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Epco also uses step-up dosing
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Discontinued treatment due to lack of response - not AE
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Grade 1 and 2 AE’s only - can be managed in outpatient settings - or at home....
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Shocking ORR
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GEN will wipe the floor with Roche
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N=12 only at optimal dose - still...
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Rituximab still SOC...
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Martin Hutchings var ikke til at tage fejl af - meget begejstret over epco. Flere årsager som sideeffects - sikkert grundet sc-version. Epco benytter ikke samme epitope på cd20 som af rituxan/gazyva, som tidligere er benyttet på patienterne. Imponerende og ikke tidligere set effekt.
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Epco - interessant - AE’s forekommer på non-responders
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Not so much on responders
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KOL - epco safer than glofitamab
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On par with glofitamab on efficacy
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