Genmab — November 2020

E_L

In the expansion cohort, which includes patients with PD-L1 relapsed/refractory NSCLC, two of 12 patients that could be objectively assessed achieved confirmed single-agent partial responses. One patient had an unconfirmed partial response and four patients demonstrated stable disease. BNT311/GEN1046 is partnered with Genmab. https://www.globenewswire.com/news-release/2020/11/10/2123650/0/en/BioNTech-Announces-Third-Quarter-2020-Financial-Results-and-Corporate-Progress.html

E_L

Presentation easier to read as earlier poster
https://investors.biontech.de/static-files/b6206133-040a-4f71-96eb-22cfcb982a52

DevOp

Thx E L, now with easily read dosing.

E_L

So on my earlier question, will they open expansion cohorts for the other diseases?' there will be 7 expansion cohorts with up to 40 patients per cohort

E_L

2x NSCLC, Urothelial, Endometrial, TNBC (Triple-negative breast cancer), SCCHN (
Squamous Cell Carcinoma of the Head and Neck) and Cervical

peter12

Judith also mentioned CR's at the cc ?

peter12

And as disclosed in the abstract, by the time of the cut, the median follow-up was 8.3 months, and 25 patients were still ongoing. And I think that with this, I give you a signal, that 25 patients were still ongoing. And if you look at the data again at the tail, in above 48 milligrams for the DLBCL from 7 patients, the ORR was 100%; CR, 28%; 72% PRs, and those patients were ongoing. So – and the FPL, same thing, above 12. And the cut is arbitrary,

Bulder

det er epco Peter

peter12

ok tak

E_L

on P20 of the presentation , fig A, the best change in SoD from baseline =-100%; does that mean the tumor disappeared?

E_L

should we conclude that Colorectal cancer and Ovarian cancer will not continue to the expansion phase?

Bulder

looks like it, both Q

E_L

what is it then that you where hoping for / expecting?

GeorgeBest

Thanks E L for the fantastic job you are doing

gdn55

Ditto her. Tak

E_L

I did - and no need to say thanks.

E_L

but seriously curious what people where expecting/ why they are disapointed. We have seen these sort of early data sets many times before now, it ususally isn't more then this

GeorgeBest

Yes, I must admit, I got carried away with Jans words again again...;-)

GeorgeBest

But I am sure they will deliver again

AaBforever

@E L What do you expect we will hear on fridag 13.?