Genmab — November 2020

[E_L]

agree, specially since most of them are not yet on the highest dose

[E_L]

it doesn't say at what dose the NSCLC expansian is, does it?

[JørgenVarnæs]

Men jeg vil ikke lægge alt for meget vægt på orr endnu - dertil er antallet af patienter for småt. Men det er jo gætværk vi er ude i her - så måske med n=30 vi har et solidt fingerpeg

[Bulder]

Ja, umiddelbart falder man jo ikke ned af stolen. Men måske kan man ikke forvente mere af så syge pts.

[Bulder]

Kan godt være at SD i virkeligheden er udmærket.

[E_L]

Not sure what you guys all expected to get, but this is a PhI dose escalation. MTD not reached, safety acceptable. and at these dose it shows efficacy. SD for patients like this is unfortunately already a big +

[E_L]

my next questoin is, can the dose still go up? will the open expansion cohorts for the other diseases? they initially enrolled most in colorectal; will it proceed?

[E_L]

On December 8 at 12:30 PM EST (6:30 PM CET / 5:30 PM GMT) Genmab will hold its virtual 2020 ASH Data Review and present its 2021 Key Priorities.

[DevOp]

If efficacy is also shown in the NSCLC pts already treated with ICI, that looks like a proof of concept

[JørgenVarnæs]

Jeg kan ikke finde nogen opdelinger af dose/indikation i dokumentet. Der er dog kun n=4 på højeste dose

[E_L]

I think Fig 6 shows the dose per patient below each patient, but i can not read that... Fig 7 also

[AaBforever]

Spændende hvor langt vi skal ned på nyhederne..:-(...måske har JvdW været for entusiastisk.

[E_L]

or maybe people don't think for themselves , start whining when the price goes down and blame that on data they don't understand

[Helge_LarsenPI-redaktør]

[Bulder]

Faldet skyldes ikke disse data. Det er sektorrotationen der fortsætter. Desværre falder det lige sammen med vore forventninger om stigninger op til CMD.

[DevOp]

E L, if you zoom in the PDF, most of the doses are "readable"

[Helge_LarsenPI-redaktør]

Enig Bulder.

[AaBforever]

Man kan godt blive lidt rundtosset med den fart rotationen har på.

[E_L]

i tried @DevOp , maybe i need new spectacles agree with your 09.54 btw. Judith also mentioned something about that

[Helge_LarsenPI-redaktør]

Novo, Bava, Zeal og Gen er ramt i dag.