Genmab — November 2020

[E_L]

A Phase 1, First-in-Human Study of Talquetamab, a G Protein-Coupled Receptor Family C Group 5 Member D (GPRC5D) x CD3 Bispecific Antibody, in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM) https://ashpublications.org/blood/article/136/Supplement 1/40/470139/A-Phase-1-First-in-Human-Study-of-Talquetamab-a-G?searchresult=1

[E_L]

very interesting. had Talquetamab as a lotery ticket, early data encouriging though, even though a few grade 3 crs
?

[E_L]

MTD has not been defined and dose escalation continues, with the study nearing a RP2D.

[Bulder]

Yes, but only grade 1-2 with sc dosing. Amd it looks that they have decided for sc, as that is the chosen adm in the combination study.

[Bulder]

301 Moved Permanently

(www.clinicaltrials.gov)

[E_L]

that is a good point. the PhII is also SC https://clinicaltrials.gov/ct2/history/NCT04557098?A=1&B=2&C=merged#StudyPageTop

[E_L]

ORR was a bit higher at IV though, probably still have to jack up the SC dose a bit

[E_L]

looks good though, no?

[Bulder]

indeed, can't wait to see the outcome in combo with dara.

[Solsen]

Knock off your socks

[AaBforever]

Gen 6%...:-)

[E_L]

Genmab Announces Data to be Presented at 2020 ASH Annual Meeting https://ir.genmab.com/news-releases/news-release-details/genmab-announces-data-be-presented-2020-ash-annual-meeting

[E_L]

Subcutaneous Epcoritamab Induces Complete Responses With an Encouraging Safety Profile Across Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma Subtypes, Including Patients With Prior CAR-T Therapy: Updated Dose-Escalation Data– Oral presentation,

[E_L]

i can't find that one online yet?

[StockBull]

AbbVie +9% - kanon dag

[Helge_LarsenPI-redaktør]

Besøgende i chatten lige nu:

1. Denmark 279

2. Luxembourg 2

3. Germany 1

4. Netherlands 11

5. Norway 1

6. Sweden 1

7. Turkey 1

8. United Arab Emirates

[Helge_LarsenPI-redaktør]

Godt vi fik installeret nye stærke servere i forsommeren.

[deleted-user]

"Det er internationalisering", citat fra Johannes Petersen. Hos PI er der dog mere substans bag udviklingen end hos Nordisk Fjer. Dejlig dag for Genmab

[Helge_LarsenPI-redaktør]

Nu er Italien også med. Vi mangler vores sædvanlige besøgende fra USA.

[nohope]

Trtump har sikkert for travlt til at kigge med i dag...