Genmab — Maj 2020
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EHA abstracts available via https://library.ehaweb.org/eha/#!*listing=1*browseby=3*sortby=2*ce_id=1550*search=daratumumab
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SUPERIOR ANTI-TUMOR ACTIVITY OF HEXABODY
-CD38 IN PRECLINICAL MODELS OF MULTIPLE MYELOMA, B CELL LYMPHOMA AND ACUTE MYELOID LEUKEMIA https://library.ehaweb.org/eha/2020/eha25th/294801/ida.h.hiemstra.superior.anti-tumor.activity.of.hexabody-cd38.in.preclinical.html?f=listing%3D1*browseby%3D8*sortby%3D2*media%3D3*ce_id%3D1766*ot_id%3D23230*search%3Ddaratumumab*marker%3D757 -
SUBCUTANEOUS EPCORITAMAB (GEN3013; CD3XCD20) IN PATIENTS WITH RELAPSED/REFRACTORY B-CELL NON-HODGKIN LYMPHOMA: DOSE-ESCALATION DATA FROM A PHASE 1/2 TRIAL https://library.ehaweb.org/eha/2020/eha25th/293707/martin.hutchings.subcutaneous.epcoritamab.28gen3013.cd3xcd2029.in.patients.with.html?f=listing%3D0*browseby%3D8*sortby%3D1*search%3Depcoritamab
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EVALUATION OF PHARMACODYNAMIC BIOMARKERS OF EPCORITAMAB (GEN3013; CD3XCD20): RESULTS FROM A PHASE 1/2 DOSE-ESCALATION STUDY IN PATIENTS WITH RELAPSED/REFRACTORY B-CELL NON-HODGKIN LYMPHOMA https://library.ehaweb.org/eha/2020/eha25th/293817/christopher.chiu.evaluation.of.pharmacodynamic.biomarkers.of.epcoritamab.html?f=listing%3D0*browseby%3D8*sortby%3D1*search%3Depcoritamab
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Tak for links E L.
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DUOHEXABODY
-CD37 SHOWS POTENT ANTI-TUMOR ACTIVITY IN PRE-CLINICAL B-CELL LYMPHOMA MODELS IN VITRO AND IN VIVO https://library.ehaweb.org/eha/2020/eha25th/293801/marije.b.overdijk.duohexabody-cd37.shows.potent.anti-tumor.activity.in.html?f=listing%3D0*browseby%3D8*sortby%3D1*search%3Dduohexabody -
tak Pensionisten - 15:14
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A PHASE 1 STUDY OF TECLISTAMAB, A HUMANIZED B-CELL MATURATION ANTIGEN (BCMA) X CD3 BISPECIFIC ANTIBODY, FOR THE TREATMENT OF RELAPSED AND/OR REFRACTORY MULTIPLE MYELOMA (RRMM) https://library.ehaweb.org/eha/2020/eha25th/295026/marie-victoria.mateos.a.phase.1.study.of.teclistamab.a.humanized.b-cell.html?f=listing%3D0*browseby%3D8*sortby%3D1*search%3Dteclistamab
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Janssens bcma car-t har 100% ORR, 86% sCR men eet dødsfald pga CRS. http://johnsonandjohnson.gcs-web.com/static-files/8d6cdaa2-dcfb-4e49-9151-fcd8162f2df5
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"CD38-knockout NK cells, which have been designed in attempt to prevent fratricide and enhance the activity of daratumumab" https://twitter.com/MM_Hub/status/1260948019689795589
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