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Genmab — April 2020

Planlagt Fastgjort Låst Flyttet Genmab
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  • K Offline
    K Offline
    kkjoel
    wrote on sidst redigeret af
    #823

    Men der er ingen sammenligninger med hvor mange af sådanne pts der blev hjemsendt uden samme behandling (eller en placebobehandling for den sags skyld), så man ved intet om hvor effektiv behandlingen er. De havde god bivirkningsprofil, ok. Det er fint. Men vi har et resultat, der viser at en vis procentdel af patienterne får det bedre efter at have være indlagt et stykke tid. Og det vifdste vi i forvejen. Vi er slet ikke i nærheden af en vaccine.

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    • L Offline
      L Offline
      lahn1
      wrote on sidst redigeret af
      #824

      Der kommer mere - Gilead also said that a government-run clinical trial evaluating remdesivir in severely ill COVID-19 patients met the study's primary endpoint. That study is being conducted by the National Institute of Allergy and Infectious Diseases, which is expected to provide additional information about that trial end of May.

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      • K Offline
        K Offline
        kkjoel
        wrote on sidst redigeret af
        #825

        Hvis det kan hjælpe pts og hospitaler er det fint.. men det er der sikkert mange andre ting der kan 😉

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        • K Offline
          K Offline
          kkjoel
          wrote on sidst redigeret af
          #826

          Ja, lahn, lad os nu se....

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          • SolsenS Offline
            SolsenS Offline
            Solsen
            wrote on sidst redigeret af
            #827

            Man mener at have noget fornuftigt og afslutter med at sige vi høres ved sidst i maj ???

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            • SolsenS Offline
              SolsenS Offline
              Solsen
              wrote on sidst redigeret af
              #828

              Jeg kunne godt forestille mig, at plasma har helbredt mange og er kørt godt ind inden. Vi er måske heldige med en effekt på 60-80%

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              • BulderB Offline
                BulderB Offline
                Bulder
                wrote on sidst redigeret af
                #829

                Solsen, du skal skelne mellem NIAID-studiet og Gileads egne 2 studier, hvor vi vil få resultarer sidst i maj. Det andet Gilead-studie (moderat): "shortly". Niaid: "upcoming)

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                • BulderB Offline
                  BulderB Offline
                  Bulder
                  wrote on sidst redigeret af
                  #830

                  Rettelse: Moderat: sidst i maj. Svær covid19 "shortly"

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                  • BulderB Offline
                    BulderB Offline
                    Bulder
                    wrote on sidst redigeret af
                    #831

                    I øvrigt ville det være bedst, hvis vi fører covid19 diskussion i covid19-chatten, når nu Helge har gjort sig den ulejlighed at oprette den.

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                    • SolsenS Offline
                      SolsenS Offline
                      Solsen
                      wrote on sidst redigeret af
                      #832

                      Ok

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                      • Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktørH Offline
                        Helge_LarsenPI-redaktør
                        wrote on sidst redigeret af
                        #833

                        Tak Bulder. 😄

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                        • E Offline
                          E Offline
                          E_L
                          wrote on sidst redigeret af
                          #834

                          i think i might have the one to blame lol

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                          • E Offline
                            E Offline
                            E_L
                            wrote on sidst redigeret af
                            #835

                            Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab https://www.nature.com/articles/s41375-020-0840-y

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #836

                              We already have seen Farydak (panobinostat) - a pan HDAC inihibitor approved for MM. I dont think Novartis ever made trials with daratumumab even though panobinostat also upregulates CD38. Tox issues with HDAC are heavy if I remember correctly

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                              • E Offline
                                E Offline
                                E_L
                                wrote on sidst redigeret af
                                #837

                                do you happen to know if JNJ owns such an inhibitor?

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                                • S Offline
                                  S Offline
                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #838

                                  but maybe its a different story with a selective HDAC6 inhibitor - so lets give ricolinostat a warm welcome in combination with daratumumab :-)'

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                                  • S Offline
                                    S Offline
                                    Sukkeralf
                                    wrote on sidst redigeret af
                                    #839

                                    I dont think so

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                                    • E Offline
                                      E Offline
                                      E_L
                                      wrote on sidst redigeret af
                                      #840

                                      😉

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                                      • S Offline
                                        S Offline
                                        Sukkeralf
                                        wrote on sidst redigeret af
                                        #841

                                        Its seems like Celgene bought Acetylon Pharmaceuticals and outsourced ricolinostat to Regenacy Pharmaceuticals

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                                        • S Offline
                                          S Offline
                                          Sukkeralf
                                          wrote on sidst redigeret af
                                          #842

                                          So I guess we will not see anything from that - nice papers but no commercial value

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