Genmab — April 2020

[E_L]

https://www.nature.com/articles/s41375-020-0810-4 Nature: Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting full art https://sci-hub.tw/https://www.nature.com/articles/s41375-020-0810-4

[E_L]

https://sci-hub.tw/https://www.nature.com/articles/s41375-020-0810-4

[E_L]

@peter i am not sure, it is a bit confusing as clinical trials still mentions Ph I , and it was only last September that they added lazertinib to the trial

[Sukkeralf]

in cancer trials you normaly calls it phase 1/2 because you always treat patients right away. Genmab got daratumumab approved in third line Dara/POM/Dex based on phase 1/2 data

[Sukkeralf]

If Janssen say they are going to file it does not matter to me if it is based on phase 1/2 data or phase 2 data

[E_L]

[peter12]

@E.L. Im refeering to a patient story I believe sounds trustworthy

[E_L]

In response to the coronavirus crisis, the company has mandated its employees to work for hospitals, nursing homes and other institutions in the public healthcare if needed, and Genmab will continue to pay their salaries.

[E_L]

Van de Winkel adds: ‘Our scientists will also use their knowledge to help with the response to coronavirus disease, to add our expertise and our insights to create an effective therapeutic candidate much more rapidly https://investinholland.com/success-stories/genmab/?utm_campaign=coschedule&utm_source=twitter&utm_medium=nfiaholland&utm_content=Genmab

[Plimsoller]

Good. We need smart people to help these days.

[E_L]

ADCT-301 Ph II seems fully accrued https://clinicaltrials.gov/ct2/history/NCT04052997?A=15&B=16&C=merged#StudyPageTop

[gdn55]

Kan ugen godkendes? Jeg er meget tilfreds, frygtede det værste.

[JKY_VH]

Den er absolut godkendt og god weekend:-)

[Solsen]

Tilfredshed herfra og god weekend

[gentogen]

EL 15.47: I am not so sure. That would be extremely quick. They are including new location in new countries in the trial so perhaps it is just for the time being they are not recruiting?

[E_L]

yes, that is certainly also possible,... i was actually happy that they finished so quick and just in time before corona shut recruitment down, but maybe exactly that happened...

[E_L]

New BMS-986253 trial: Anti-Interleukin-8 (Anti-IL-8) for Cancer Patients With COVID-19
https://clinicaltrials.gov/ct2/show/NCT04347226

[Solsen]

Thanks EL you are a master

[E_L]

haha, fortunately there are enough here to correct all my mistakes

[Solsen]

Well we dont know about ADC-301. You could be right...