Genmab — Januar 2020

E_L

but do we know yet if that will be an improvement vs IV for infections,
like Dara?

Bulder

I don't think sc is improving the matter of infections. It's infusion reactions. And I haven

Bulder

haven't seen anything on Isa sc.

E_L

yes, i was using indeed the wrong word

Solsen

https://pubs.acs.org/doi/pdf/10.1021/acsnano.9b08347# Måske noget spændende fra Genmabs medarbejdere. Desværre ikke tilgængelig i fuld version.

E_L

full version is here https://sci-hub.tw/https://pubs.acs.org/doi/pdf/10.1021/acsnano.9b08347#

E_L

another 'easy to read' article; good luck with it lol

Solsen

Thanks I will try

Bulder

Found this one: https://en.wikipedia.org/wiki/Oligomer

Bulder

I think it's about the clustering of antibodies under certain circumstances. The well known hexamers - which led to the hexabody - is one example. Oligomers are only different number of units in the cluster. Dimer is 2. Trimer is 3 and hexamer is 6.

Bulder

This mechanism - the forming of a cluster through the fc-part when the other end of the antibody (the fab-arms) binds to the antigen - is activating CDC reaction of the immune system. Thats how I understand it.

Bulder

E L, you have linked to the sci.hub before. But they never work. I think there is a kind of blockade of the link, as it it considered a "pirate"-site. Maybe it is limited to Denmark.

Solsen

Think PI is the pirate site

peter12

Linket til Sci.hub virker hvis man bruger en webproxy fra fx holland

Bulder

... hvordan gør man det, Peter?

Bulder

Helge = kaptajn Sortskæg?

peter12

Skriv webproxy i google og tag den der starter med hide

Bulder

tak - nu har du vist ledt mig ud i noget snavs

peter12

For den rene er alting rent, som du ved

Bulder

Well, it's a long story I can see. Much above my capacity. But I think they present the science and discoveries that led to the hexabody technology.