Genmab — Januar 2020

[E_L]

The CD38low natural killer cell line KHYG1 transiently expressing
CD16F158V in combination with daratumumab targets multiple
myeloma cells with minimal efector NK cell fratricide https://sci-hub.tw/https://link.springer.com/article/10.1007/s00262-019-02477-8

[E_L]

way to difficult article for me, dealing with the depletion of NK
cells. Interestingly though, they use mRNA technology to search for a solution

[Bulder]

Would be nice if they found a method to minimize infections.

[E_L]

so
we are not the only ones thinking that Dara should be added to the drinking water https://twitter.com/IMFjimMYELOMA/status/1215669209058799616

[bibob]

Yes. McJean was right. Add it to everything drinkable.

[Bulder]

draft dara beer - probably the best beer in town

[bibob]

I will drink on that. ;-). And good weekend all.

[E_L]

Future Direction of CD38 Antibodies in Multiple Myeloma https://www.youtube.com/watch?v=d6s2jqaafL0

[E_L]

Case 2: Overcoming High Risk in Myeloma https://www.youtube.com/watch?v=nCWXvR7kOz8

[E_L]

more from Adriana Rossi here https://www.targetedonc.com/investigator-perspectives/target-cd38-rr-mm/the-impact-of-cd38-targeted-therapy-in-multiple-myeloma

[Bulder]

Thx E L. In this one she says that Isa doesn't need as much pre-medication as dara. https://www.targetedonc.com/investigator-perspectives/target-cd38-rr-mm/icaria-mm-phase-iii-trial-overview

[StockBull]

Morn I og med der IKKE er kommet profit warning fra Genmab kan vi vel nu konkludere de 3 mia er hjemme. Da der allerede er guided med de 3 mia kommer der vel ikke nødvendigvis en pressemeddelelse så mon ikke vi skal afvente JNJ årsregnskab

[GeorgeBest]

Det trog jeg ikke du kan konkludere

[GeorgeBest]

Jeg Thor mere på at JNJ endnu ikke har givet Genmab besked

[GeorgeBest]

tror

[StockBull]

Ja det er nok det mest sandsynlige

[StockBull]

Men hvis alt er indenfor guiding så kommer der vel nødvendigvis IKKE en meddelelse ?

[Helge_LarsenPI-redaktør]

Jim Omel på Twitter: "I’ve yet to see a negative report on Dara. If it were oral (which it’s not), it should be in the drinking water of myeloma pts! Oh my"!https://conquer-magazine.com/ash-2019-mm-wrap-up?view=article&artid=1128:daratumumab-added-to-standard-therapy-longer-survival-in-newly-diagnosed-multiple-myeloma&utm_source=bronto&utm_medium=email&utm_term=Daratumumab+Added+to+Standard+Therapy+%3D+Longer+Survival+in+Newly+Diagnosed+Multiple+Myeloma&utm_content=The+Latest+in+Multiple+Myeloma

[JKY_VH]

Der må komme en meddelelse når milestonen udløses. Hvis ikke kommer der en nedjustering. Så en eller anden form for melding må der komme.

[Bulder]

Det er også min formodning. Vi får besked under alle omstændigheder.