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Genmab — November 2019

Planlagt Fastgjort Låst Flyttet Genmab
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  • E Offline
    E Offline
    E_L
    wrote on sidst redigeret af
    #914

    timing wise it would makes sense as BioNtech and Aduro/BioNovion both partnered with Genmab in 2015? if i am not mistaken...

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    • E Offline
      E Offline
      E_L
      wrote on sidst redigeret af
      #915

      so given recent trials with BioNtech I mean, could be time for Aduro

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      • E Offline
        E Offline
        E_L
        wrote on sidst redigeret af
        #916

        “The achievement of starting a Phase I/IIa clinical trial with a product candidate developed in only four years is a validation of our highly productive partnership with Genmab,” said Prof. Ugur Sahin, CEO of BioNTech - RE timing

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        • S Offline
          S Offline
          Sukkeralf
          wrote on sidst redigeret af
          #917

          Aduro and Genmab has terminated their collaboration

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          • E Offline
            E Offline
            E_L
            wrote on sidst redigeret af
            #918

            o really? i missed that...

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            • BulderB Offline
              BulderB Offline
              Bulder
              wrote on sidst redigeret af
              #919

              Sukker, hvad mener du om den bispecifikke car-t - bcma x cd38. Jacob Plieth nævner den ikke. Men Usmani er begejstret. https://ash.confex.com/ash/2019/webprogram/Paper130340.html

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              • S Offline
                S Offline
                Sukkeralf
                wrote on sidst redigeret af
                #920

                This collaboration was
                terminated in the fourth quarter of 2018.

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                • S Offline
                  S Offline
                  Sukkeralf
                  wrote on sidst redigeret af
                  #921

                  Page 41

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                  • S Offline
                    S Offline
                    Sukkeralf
                    wrote on sidst redigeret af
                    #922

                    https://ir.genmab.com/static-files/2d42acad-9313-4900-9e0e-12c6cf16f10d

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                    • E Offline
                      E Offline
                      E_L
                      wrote on sidst redigeret af
                      #923

                      ok , thks, the paper may have started before, it reads "Financial support for this work was obtained
                      from Aduro Biotech Europe and Genmab." Given that the Genmab authors get "Acknowledgments" it may be Aduro that now runs with it?

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                      • G Offline
                        G Offline
                        GeorgeBest
                        wrote on sidst redigeret af
                        #924

                        flot stigning i dag. specielt når der tages i betragtning at der blev exercised warrants i går aftes. der bliver nok hæftig aktivitet i lukkeauktionen...

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                        • S Offline
                          S Offline
                          Sukkeralf
                          wrote on sidst redigeret af
                          #925

                          E L - you are probably right

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                          • S Offline
                            S Offline
                            Sukkeralf
                            wrote on sidst redigeret af
                            #926

                            Bulder har ikke set på den endnu

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                            • S Offline
                              S Offline
                              Sukkeralf
                              wrote on sidst redigeret af
                              #927

                              Bulder data ser meget stærke ud, men altid svært med CAR-T - uden at kende meget til området som sådan, så lyder det umiddelbart endnu mere kompliceret, så svært at vurdere potentialet salgsmæssigt !

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                              • BulderB Offline
                                BulderB Offline
                                Bulder
                                wrote on sidst redigeret af
                                #928

                                Men det virker "oplagt" at lave en cd38x bcma netop i MM. Sjovt at ingen har fundet på netop den "kombi" for en almindelig bispecifik.

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                                • S Offline
                                  S Offline
                                  Sukkeralf
                                  wrote on sidst redigeret af
                                  #929

                                  måske endnu bedre med Janssens BCMA-CD3 i kombi med daratumumab 🙂

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                                  • BulderB Offline
                                    BulderB Offline
                                    Bulder
                                    wrote on sidst redigeret af
                                    #930

                                    ... eller den forstærkede hex-cd38 😉

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                                    • Legolas23L Offline
                                      Legolas23L Offline
                                      Legolas23
                                      wrote on sidst redigeret af
                                      #931

                                      Jeg mener JDW er spurgt om hex-cd38?

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                                      • S Offline
                                        S Offline
                                        Sukkeralf
                                        wrote on sidst redigeret af
                                        #932

                                        Alligevel også lidt svært at forestille sig hvis ikke Janssen har kigget på dara som bispecific - måske grunden til at de kun delvist er sprunget med på hex-CD38. Det kan være der er et bispecifict CD38 antistof i rugekassen

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                                        • SolsenS Offline
                                          SolsenS Offline
                                          Solsen
                                          wrote on sidst redigeret af
                                          #933

                                          Mener vi en gang har spurgt til det og fik at vide at CD3 x CD38 ikke var en god kombi ?

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