Genmab — Oktober 2019

[Bulder]

I wonder if they are considering a limitation of the indication. We have this problem with Cassiopeia as well as Griffin, that high risk pts don't really benefit from adding dara. In Cassiopeia they do benefit a little, but that is because VTd is a "weaker" combination. In Griffin HR-pts don't benefit at all, as VRd is a better combination. So for 15% of pts it would be waste of money to add dara.

[Bulder]

That said, it's still early days with Griffin. It could be better over time. And Griffin is only a small study. Perseus will show us how things really are concerning HR pts.

[E_L]

Are you suggesting JNJ would put a limitation? I doubt they'll do that.... But I agree MD's will be less likely to choose it for HR patients

[Bulder]

Voorhees himself has spoken about it. Be cautious with HR, if you start to use D-VRd now already. No not JnJ. The authorities.

[E_L]

do you think there is enough sub-data for them to do that already?

[Bulder]

For standard-risk, yes. Or what do You mean?

[E_L]

i was thinking if there were enough patients in that subgroup HR to make that conclusion, but there are i think, just checked https://multiplemyelomahub.com/medical-information/imw-2019-subgroup-analysis-cassiopeia

[E_L]

the press release from Janssen https://www.businesswire.com/news/home/20191018005289/en/CHMP-Grants-Positive-Opinion-Expanded-Janssen’s-Darzalex▼

[Bulder]

And in Griffin as well: Dr. Voorhees noted that D-RVd was favored across all subgroups for MRD negativity and stringent compete response, except among patients with high-risk cytogenetics and stage III disease. https://www.mdedge.com/hematology-oncology/article/208465/multiple-myeloma/combo-could-be-new-standard-transplant-eligible

[Plimsoller]

De dårlige nyheder bliver ved med at vælte ned over JJ.

[Plimsoller]

Siden findes ikke

(borsen.dk)

[Helge_LarsenPI-redaktør]

1.409,50.

[bibob]

Ja, dejligt med luk over 1400 til weekend. :-). God weekend til alle.

[polle1]

Flot og stærkt ift. det generelle marked, god weekend

[Helge_LarsenPI-redaktør]

Ugens Vindere og tabere: Sydbank, H+H, Chemometec og Genmab i top: https://www.proinvestor.com/investornyt/644447/ugens-vindere-og-tabere-sydbank-h-h-chemometec-og-genmab-i-top

[Helge_LarsenPI-redaktør]

Servicemeddelelse til alle natteravne: Vi arbejder på websiden l. Derfor er den enten periodisk nede eller ser kaos-agtig ud. Vi bliver måske først færdig i nat. I morgen tidlig er vi klar igen med nyhederne fra de globale aktiemarkeder.

[Helge_LarsenPI-redaktør]

Vi arbejder bla. i aften på at få en Chemometec-chat op. Vi vil gerne for at gøre det nemmere for brugerne at tilgå chatten uden om indmelding i en gruppe. Koderne driller lidt på dette område.

[Helge_LarsenPI-redaktør]

God morgen.

[Helge_LarsenPI-redaktør]

Ny Chemometec chat. https://www.proinvestor.com/index.php?p=group&groupid=106

[Bella1]

Flidspræmie overføres mandag!