Genmab — Oktober 2019
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Nu vi er ved isa. Ud over at de altså allerede har en sc-version i klinikken, så kører de ufortrødent på med isa+atezo i solide. https://www.clinicaltrials.gov/ct2/show/NCT03637764?term=isatuximab+atezolizumab&rank=1
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Analysehus: MSD's Keytruda bliver verdens bedst sælgende lægemiddel i 2025
En fremskrivning fra analysehuset Globaldata viser, at MSD's kræftmiddel Keytruda vil være verdens bedst sælgende lægemiddel om fem år, mens den nuværende topsællert, Abbvies inflammationsmidddel Humira, vil falde til nummer seks.
(medwatch.dk)
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Der kan være lidt her: However, one particular difference is that unlike Darzalex, it is not associated with complement activation, meaning it can be more readily given to patients with asthma or chronic obstructive pulmonary disease.
“It’s not a trivial population,” said Dr. Paul Richardson. https://medcitynews.com/2019/06/sanofis-isatuximab-shines-in-myeloma-at-asco-but-where-will-it-fit-into-treatment/?rf=1 -
Der kører da forsøg med dara i solide ? https://www.clinicaltrials.gov/ct2/show/NCT03098550?term=daratumumab+solid&rank=2
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Cetrelimab hedder JNJ PD1 https://clinicaltrials.gov/ct2/show/NCT02908906
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Solsen tror absolut heller ikke isatuximab vil erstatte daratumumab, men der kommer trods alt en del Mm drugs på makredet - og hvis enkelte af dem nupper en halv til hel milliard dollars af omsætningen, så kan det være peaksale måske ender 1-3 milliarder dollars lavere i MM
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de 1-3 milliarder USD kan amyloidosis så passende kompensere for...
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Lebowitz said that in that earlier lung trial the concern was that steroids are taking away from the immune response. He adds: we have developped (and into the clinic) a steroid sparing regimen where we can get the streroids off -and we needed the SC to do that
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Mht BMS-studierne i solide - dara-nivo - er der ikke meget tilbage. Der var vist 3. Det ene er lukket for rekruttering https://www.clinicaltrials.gov/ct2/show/NCT03098550?term=daratumumab+nivolumab&rank=2 Det andet er lukket i dara cohorten https://www.clinicaltrials.gov/ct2/show/NCT02488759?term=daratumumab+nivolumab&rank=4
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