Genmab — August 2019
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!! Daratumumab synergizes with R-CHOP to reduce tumor burden in preclinical models of MCL and FL (...) In conclusion, these data demonstrate the value of the combination R-D-CHOP as a new
therapeutic strategy in MCL and tFL superior to the standard of care (R-CHOP) -
providing a strong rationale for examining its clinical efficacy in different scenarios, including
maintenance therapy after induction therapy, cases with anti-CD20 resistance, FL histologic
transformation, and as frontline in combination with the standard of care (CHOP/ R-CHOP) -
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