Genmab — Januar 2019

E_L

Also the first dose split in 2 will make a difference; currently some hospitals ask patients to come in the night before and thus spend overnight before the first infusion, very costly and time consuming.

Solsen

Man mener, at sc-dara vil kunne konverteres til alle godkendte linier - hvis forsøget falder godt ud. Jeg er ikke så meget i tvivl om effekt og sideeffekt. Kun at dara konc i blod ser ud til at være en streg højere end i 16 mg settings kan give problemer - men næppe relevant hvis sideeffects og effekt begge går i rigtig retning.

JørgenVarnæs

...er det NCT03412565 (fase2), der er det pivotale i 1st line SC? Den har primary completion I Q3 19

JørgenVarnæs

indeholder 199 patienter

Bulder

Ja, det er det som sammen med Columba skal danne basis for generel anvendelse af sc

JørgenVarnæs

ok - så vi har en horisont på lige nord for 12 måneder for SC I alle linier

Bulder

Ja, vi får nok ikke sc med under RTOR, da der er tale om en ny formulering

nohope

EL. The solution is easy, let the old fragile patients have daytime, since they are not working and let the strong younger patients in work have the evening/night shift.

Bulder

nohope, all patients are old and frail in Maia

E_L

Q&A Feb18 - Q: In january you started a “Study to evaluate Subcutaneous Daratumumab in
combination with Standard Multiple Myeloma Treatment Regimens”, which is a Phase
2. You already have the Phase 3 SC vs IV study; could these 2 clinical trials be the
basis for an overall approval of SC in all lines and settings?
Jan : This is a good thought.

nohope

I´ve never understood why split dosing is such a great improvement. You have to take same dosis over 2 days. Same patient must be at the hospital twice as many times and be cleared for treatment. You have to do all the manuel procedures twice against a small time gain ?

Bulder

You'll have to wait for the asct setting to meet the young ones.

E_L

@nohope ; i would take that night chair. unfortunately i think most would not

nohope

#Bulder. Maybe Bulder, but EL wrote as if as there were 2 different groups of patients. One fragile and one in work.

E_L

most are fragile AND in work lol

E_L

well, not lol really

Bulder

Det har vi diskuteret før, hohope og linket til ameriknske hospitaler og deres begrundelse for at foretrække split-dosing. Det er simpelt hen nemmere at administrere rent praktisk.

nohope

Det skal ikke være nemt, det skal være effektivt- størst mulige gode for flest mulige.

AaBforever

Mon der er warrants ude? Danske største nettosælger.

JørgenVarnæs

der vil være en meddelelse fra selskabet aftenen før bølgen af warrants-salg