Genmab — November 2018
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SITC har frigivet abstracts i dag og dara bliver nævnt ifm CLL https://www.sitcancer.org/2018/abstracts/titles
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Angående tidligere: International Immunology, Volume 30, Issue 8, 24 July 2018, Pages 375–383: the combination of ATRA and DARA has potent anti-leukemic effects, mediated through CD38 up-regulation and antibody-induced fratricide, in vitro and in vivo. Indeed, within the murine models, combination treatment led to reduced tumor size and growth rate and a 46.6% increase in mean survival time
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Ang. 16:03. Fra andet studie: "The toxicity profile was mild and reversible. No secondary carcinoma was observed, and 24 months after the last dose of ATRA/ATO, patients had urine arsenic concentrations well below the safety limit. These results demonstrate the high efficacy and minimal toxicity of ATRA/ATO treatment for newly diagnosed APL in long-term follow-up"
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